• Publications
  • Influence
Cryptic Pol II Transcripts Are Degraded by a Nuclear Quality Control Pathway Involving a New Poly(A) Polymerase
Since detection of an RNA molecule is the major criterion to define transcriptional activity, the fraction of the genome that is expressed is generally considered to parallel the complexity of theExpand
  • 779
  • 86
Transcription termination and nuclear degradation of cryptic unstable transcripts: a role for the nrd1-nab3 pathway in genome surveillance.
Cryptic unstable transcripts (CUTs) are widely distributed in the genome of S. cerevisiae. These RNAs generally derive from nonannotated regions of the genome and are degraded rapidly and efficientlyExpand
  • 237
  • 27
THO/Sub2p Functions to Coordinate 3′-End Processing with Gene-Nuclear Pore Association
During transcription, proteins assemble sequentially with nascent RNA to generate a messenger ribonucleoprotein particle (mRNP). The THO complex and its associated Sub2p helicase are functionallyExpand
  • 145
  • 12
The Cul4-Ddb1Cdt2 Ubiquitin Ligase Inhibits Invasion of a Boundary-Associated Antisilencing Factor into Heterochromatin
Partitioning of chromosomes into euchromatic and heterochromatic domains requires mechanisms that specify boundaries. The S. pombe JmjC family protein Epe1 prevents the ectopic spread ofExpand
  • 74
  • 6
Ers1, a Rapidly Diverging Protein Essential for RNA Interference-dependent Heterochromatic Silencing in Schizosaccharomyces pombe*
Centromeric silencing and heterochromatin formation in Schizosaccharomyces pombe require the RNA interference (RNAi) machinery. Three factors that mediate this mechanism have been identified: 1) theExpand
  • 18
  • 2
Ers1 links HP1 to RNAi
Pericentromeric heterochromatin formation is mediated by repressive histone H3 lysine 9 methylation (H3K9Me) and its recognition by HP1 proteins. Intriguingly, in many organisms, RNAi is coupled toExpand
  • 22
  • 1
Implication of Ccr4-Not complex function in mRNA quality control in Saccharomyces cerevisiae.
Production of messenger ribonucleoprotein particles (mRNPs) is subjected to quality control (QC). In Saccharomyces cerevisiae, the RNA exosome and its cofactors are part of the nuclear QC machineryExpand
  • 23
High-frequency promoter firing links THO complex function to heavy chromatin formation.
The THO complex is involved in transcription, genome stability, and messenger ribonucleoprotein (mRNP) formation, but its precise molecular function remains enigmatic. Under heat shock conditions,Expand
  • 15
Interactions entre transcription, maturation et dégradation des ARNs chez Saccharomyces cerevisiae
Chez la levure Saccharomyces cerevisiae, l’exosome est un large complexe possedant une activite exonuclease 3’-5’ et participant a de nombreuses reactions de maturation et de degradation de l’ARN.Expand