Receptor Down-Regulation

Known as: Down-Regulation, Receptor, Receptor Down Regulation, receptor downregulation 
A negative regulatory process that decreases ligand-receptor interactions. Reduction in receptor binding after ligand exposure can result from the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1980-2018
05019802018

Papers overview

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Highly Cited
2006
Highly Cited
2006
UBPY is a ubiquitin-specific protease that can deubiquitinate monoubiquitinated receptor tyrosine kinases, as well as process Lys… (More)
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Highly Cited
2006
Highly Cited
2006
Targeting tyrosine kinase receptors (RTKs) with specific Abs is a promising therapeutic approach for cancer treatment, although… (More)
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Highly Cited
2005
Highly Cited
2005
Ligand-activated receptor tyrosine kinases undergo endocytosis and are transported via endosomes to lysosomes for degradation… (More)
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Highly Cited
2003
Highly Cited
2003
Down-regulation of mitogenic signaling in mammalian cells relies in part on endosomal trafficking of activated receptors into… (More)
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Highly Cited
2001
Highly Cited
2001
Large scale sequencing of the human mu-opioid receptor (hMOR) gene has revealed polymorphic mutations that occur within the… (More)
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Highly Cited
2000
Highly Cited
2000
Estrogen receptor-alpha (ER alpha) is downregulated in the presence of its cognate ligand, estradiol (E2), through the ubiquitin… (More)
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Highly Cited
1997
Highly Cited
1997
Interaction of type I collagen (COL(I)) with alpha2beta1 integrin causes differentiation and transforming growth factor (TGF… (More)
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Highly Cited
1997
Highly Cited
1997
Ligation of CCR5 by the CC chemokines RANTES, MIP-1alpha or MIP-1beta, and of CXCR4 by the CXC chemokine SDF-1alpha, profoundly… (More)
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Highly Cited
1996
Highly Cited
1996
Four transmembrane tyrosine kinases constitute the ErbB receptor family: the epidermal growth factor (EGF) receptor, ErbB-2, ErbB… (More)
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Highly Cited
1994
Highly Cited
1994
5-HT2C receptor antagonists, such as mianserin and mesulergine, exhibit negative intrinsic activity, defined as a decrease in… (More)
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