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Receptor Down-Regulation

Known as: Down-Regulation, Receptor, Receptor Down Regulation, receptor downregulation 
A negative regulatory process that decreases ligand-receptor interactions. Reduction in receptor binding after ligand exposure can result from the… 
National Institutes of Health

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Broader (1)

Down-Regulation
PTGFRN genePTGFRN wt AlleleProstaglandin F2 Receptor Negative Regulatorreceptor expression

Papers overview

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Review
2006
Review
2006
Raf kinase inhibitor protein regulation of raf and MAPK signaling.
2001
2001
Cortical 5-HT1A receptor downregulation by antidepressants in rat brain
Highly Cited
2000
Highly Cited
2000
The C Terminus of the Saccharomyces cerevisiaeα-Factor Receptor Contributes to the Formation of Preactivation Complexes with Its Cognate G Protein
ABSTRACT Binding of the α-factor pheromone to its G-protein-coupled receptor (encoded by STE2) activates the mating pathway… 
Highly Cited
1995
Highly Cited
1995
Identification of Phenylalanine 346 in the Rat Growth Hormone Receptor as Being Critical for Ligand-mediated Internalization and Down-regulation (*)
The functional significance of growth hormone (GH) receptor (GHR) internalization is unknown; therefore, we have analyzed domains… 
Review
1995
Review
1995
Modulation of insulin action by vanadate: evidence of a role for phosphotyrosine phosphatase activity to alter cellular signaling
A number of vanadium compounds (vanadate, vanadyl sulfate, metavanadate) have insulin-mimicking actions bothin vitro andin vivo… 
Review
1993
Review
1993
Aspects of benzodiazepine receptor structure and function with relevance to drug tolerance and dependence.
Potential development of tolerance to and dependence on benzodiazepine tranquilizers often limit their use for long-term… 
Highly Cited
1988
Highly Cited
1988
Role of tyrosine kinase and membrane-spanning domains in signal transduction by the platelet-derived growth factor receptor
Three types of mutations were introduced into the platelet-derived growth factor (PDGF) receptor to cause a loss of PDGF… 
1987
1987
Regulation of the beta-receptor-adenylate cyclase system in lymphocytes of allergic patients with asthma: possible role for protein kinase C in allergen-induced nonspecific refractoriness of…
Highly Cited
1984
Highly Cited
1984
Myocardial β-adrenergic receptor downregulation in heart failure
1980
1980
The effects of interferon on epidermal growth factor action.
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