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Receptor Down-Regulation

Known as: Down-Regulation, Receptor, Receptor Down Regulation, receptor downregulation 
A negative regulatory process that decreases ligand-receptor interactions. Reduction in receptor binding after ligand exposure can result from the… 
National Institutes of Health

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Down-Regulation
PTGFRN genePTGFRN wt AlleleProstaglandin F2 Receptor Negative Regulatorreceptor expression

Papers overview

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2002
2002
EGF receptor downregulation depends on a trafficking motif in the distal tyrosine kinase domain.
On binding to its receptor, epidermal growth factor (EGF) initiates a cascade of events leading to cell proliferation or… 
1998
1998
The complementary role of glucocorticosteroids and long‐acting β‐adrenergic agonists
In summary, beta 2-adrenergic agonists and corticosteroids can interact to produce beneficial effects on airway function. The… 
1995
1995
Long-term Treatment With Angiotensin I–Converting Enzyme Inhibitors Attenuates the Loss of Cardiac β-Adrenoceptor Responses in Rats With Chronic Heart Failure
Background Cardiac contractile force in response to β-adrenoceptor agonists and β-adrenergic receptor density are decreased in… 
1993
1993
Mutation of tyrosine-350 impairs the coupling of the beta 2-adrenergic receptor to the stimulatory guanine nucleotide binding protein without interfering with receptor down-regulation.
Long-term stimulation of the beta 2-adrenergic receptor (beta 2AR) leads to an internalization and degradation of the receptor… 
1992
1992
Staphylococcus aureus alpha-toxin permeabilizes the basolateral membrane of a Cl(-)-secreting epithelium.
Apical membrane ion channels control the rate of transepithelial electrolyte transport in many epithelia. One way to study such… 
1990
1990
Regulation of Bradykinin Action at the Receptor Level
Intact cultured human foreskin fibroblasts can be used as an in vitro system to study the regulatory events related to kinin… 
1989
1989
Effects of TCDD on the EGF receptor of XB mouse keratinizing epithelial cells.
TCDD was found to cause a marked inhibition of 125I-epidermal growth factor (EGF) binding to its receptor on the cell surface of… 
1986
1986
Insulin receptor processing as a function of erythrocyte age. A kinetic model for down-regulation.
The effects of cell aging on insulin binding and on insulin receptor processing in human erythrocytes were studied. Erythrocytes… 
1985
1985
EGF induces receptor down‐regulation with no receptor recycling in KB cells
Several ligands, including epidermal growth factor (EGF), have been found to negatively modulate or down‐regulate their specific… 
1981
1981
Insulin receptor down-regulation, prevention at a post-receptor site.
Nicotinamide (50mM) prevented insulin-mediated down-regulation of insulin receptors in IM-9 lymphoblastoid cells. Half-maximum… 
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