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Down-Regulation

Known as: Down Regulation, Down-Regulation (Physiology), Downregulation 
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory… 
National Institutes of Health

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Receptor Down-Regulation
Up-Regulation (Physiology)aspects of radiation effectsphysiological aspects

Papers overview

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Highly Cited
2007
Highly Cited
2007
The increased expression of Y box‐binding protein 1 in melanoma stimulates proliferation and tumor invasion, antagonizes apoptosis and enhances chemoresistance
In previous studies we identified the transcription/translation factor Y‐box‐binding protein (YB‐1) as a gene that is upregulated… 
Highly Cited
2004
Highly Cited
2004
Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP
The cytotoxic effect of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is limited in many glioma cell lines… 
Highly Cited
1998
Highly Cited
1998
Regulation of Microtubule Dynamics by Extracellular Signals: cAMP-dependent Protein Kinase Switches Off the Activity of Oncoprotein 18 in Intact Cells
Oncoprotein 18 (Op18, also termed p19, 19K, metablastin, stathmin, and prosolin) is a recently identified regulator of… 
Highly Cited
1996
Highly Cited
1996
Bidirectional Regulation of Protein Kinase Mζ in the Maintenance of Long-Term Potentiation and Long-Term Depression
Long-term potentiation (LTP) and long-term depression (LTD) are persistent modifications of synaptic efficacy that may contribute… 
Highly Cited
1996
Highly Cited
1996
Compensatory mechanisms associated with the hyperdynamic function of phospholamban-deficient mouse hearts.
Phospholamban ablation is associated with significant increases in the sarcoplasmic reticulum Ca(2+)-ATPase activity and the… 
Highly Cited
1995
Highly Cited
1995
Subsensitivity of bronchodilator and systemic beta 2 adrenoceptor responses after regular twice daily treatment with eformoterol dry powder in asthmatic patients.
BACKGROUND--There is controversy as to the role of long acting beta 2 agonists such as eformoterol and, in particular, whether… 
Review
1994
Review
1994
Actions of redox-related congeners of nitric oxide at the NMDA receptor
Highly Cited
1991
Highly Cited
1991
Hypothermia Prevents the Ischemia‐Induced Translocation and Inhibition of Protein Kinase C in the Rat Striatum
: The effect of hypothermia on the ischemia‐induced changes in the subcellular distribution of protein kinase C (PKC)(γ), ‐(βII… 
Highly Cited
1986
Highly Cited
1986
Substance P: binding properties and studies on cellular responses in guinea pig macrophages.
The neuropeptide Substance P (SP) has been recognized to modulate functional activities of inflammatory cells. We have previously… 
Highly Cited
1981
Highly Cited
1981
Differential Time Course of Glucagon's Effect on Glycogenolysis and Gluconeogenesis in the Conscious Dog
The evanescence of glucagon's effect on glucose production (GP) is well documented, but it is unclear (1) whether this response… 
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