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Down-Regulation

Known as: Down Regulation, Down-Regulation (Physiology), Downregulation 
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory… 
National Institutes of Health

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Receptor Down-Regulation
Up-Regulation (Physiology)aspects of radiation effectsphysiological aspects

Papers overview

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2017
2017
Downregulated SOCS 1 expression activates the JAK 1 / STAT 1 pathway and promotes polarization of macrophages into M 1 type
Macrophage polarization is flexible, and involves in different signaling pathways and various transcription factors. Suppressor… 
Review
2017
Review
2017
Medicinal Plants Used for Treatment of Rheumatoid Arthritis : A
The objective of this present review is to evaluate the therapeutic potential of Zingiber officinale in rheumatoid arthritis. We… 
2015
2015
C 6 ceramide dramatically increases vincristine sensitivity both in vivo and in vitro , involving AMP-activated protein kinase – p 53 signaling
Use of the conventional cancer chemotherapy (i.e. vincristine) is limited in tumor cells exhibiting pre-existing or acquired… 
2005
2005
Resveratrol inhibits rhabdomyosarcoma cell proliferation
Rhabdomysarcoma is the most common soft tissue tumour in children under the age of 15. Although the introduction of multimodal… 
1997
1997
In vitro and in vivo modulation of alpha- and beta-glucocorticoid-receptor mRNA in human bronchial epithelium.
Despite the central role bronchial epithelial cells play in asthmatic reactions, and the widespread use of inhaled… 
1996
1996
Intestinal cell cycle regulations. Interactions of cyclin D1, Cdk4, and p21Cip1.
OBJECTIVE The p21Cip1 protein is a potent stoichiometric inhibitor of cyclin-dependent kinase activity, and p21Cip1 mRNA… 
Review
1995
Review
1995
Induction of the stress response to prevent organ injury.
Septic shock, multiorgan dysfunction, and the acute respiratory distress syndrome are major contributors to morbidity and… 
1994
1994
Mechanisms underlying the augmented responses of deoxycorticosterone acetate‐salt hypertensive rats to neutral endopeptidase inhibitors
Objective To explore the mechanisms for augmented neutral endopeptidase inhibitor-induced natriuresis in deoxycorticosterone… 
1992
1992
Oxidatively modified HDLs are potent inhibitors of cholesterol biosynthesis in human skin fibroblasts.
Several biological properties of lipoproteins are modified by oxidative reactions. Modified lipoproteins are rapidly degraded by… 
1985
1985
Insulin-induced Desensitization at the Receptor and Postreceptor Level in Mitogen-activated Human T-Lymphocytes
Human T-lymphocytes activated by phytohemagglutin acquire insulin receptors in culture. Saturation analysis of insulin-binding…