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Down-Regulation

Known as: Down Regulation, Down-Regulation (Physiology), Downregulation 
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory… 
National Institutes of Health

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Receptor Down-Regulation
Up-Regulation (Physiology)aspects of radiation effectsphysiological aspects

Papers overview

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Highly Cited
2011
Highly Cited
2011
Protection of SH-SY5Y Neuronal Cells from Glutamate-Induced Apoptosis by 3,6′-Disinapoyl Sucrose, a Bioactive Compound Isolated from Radix Polygala
The neuroprotective effects of 3,6′-disinapoyl sucrose (DISS) from Radix Polygala against glutamate-induced SH-SY5Y neuronal… 
Highly Cited
2004
Highly Cited
2004
Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP
The cytotoxic effect of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is limited in many glioma cell lines… 
Highly Cited
1997
Highly Cited
1997
Human Histocompatibility Leukocyte Antigen (HLA)-G Molecules Inhibit NKAT3 Expressing Natural Killer Cells
The crucial immunological function of the classical human major histocompatibility complex (MHC) class I molecules, human… 
Highly Cited
1996
Highly Cited
1996
Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase
The association of PTP1C deficiency with the multiplicity of lymphoid cell abnormalities manifested by motheaten (me) and viable… 
Highly Cited
1996
Highly Cited
1996
Bidirectional Regulation of Protein Kinase Mζ in the Maintenance of Long-Term Potentiation and Long-Term Depression
Long-term potentiation (LTP) and long-term depression (LTD) are persistent modifications of synaptic efficacy that may contribute… 
Highly Cited
1995
Highly Cited
1995
Subsensitivity of bronchodilator and systemic beta 2 adrenoceptor responses after regular twice daily treatment with eformoterol dry powder in asthmatic patients.
BACKGROUND--There is controversy as to the role of long acting beta 2 agonists such as eformoterol and, in particular, whether… 
Review
1994
Review
1994
Actions of redox-related congeners of nitric oxide at the NMDA receptor
Highly Cited
1986
Highly Cited
1986
Substance P: binding properties and studies on cellular responses in guinea pig macrophages.
The neuropeptide Substance P (SP) has been recognized to modulate functional activities of inflammatory cells. We have previously… 
Highly Cited
1984
Highly Cited
1984
Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts
The metabolism of the receptor for epidermal growth factor (EGF) has been measured by labeling the receptor in vivo with… 
Highly Cited
1981
Highly Cited
1981
Differential Time Course of Glucagon's Effect on Glycogenolysis and Gluconeogenesis in the Conscious Dog
The evanescence of glucagon's effect on glucose production (GP) is well documented, but it is unclear (1) whether this response… 
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