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Overview of the European and North American studies on HPV testing in primary cervical cancer screening
Several studies suggest that HPV testing is more sensitive than cytology in primary cervical screening. These studies had different designs and were reported in different ways. Individual patient… Expand
TLR9 Expression and Function Is Abolished by the Cervical Cancer-Associated Human Papillomavirus Type 161
Cervical cancer development is linked to the persistent infection by high-risk mucosal human papillomaviruses (HPVs) types. The E6 and E7 major oncoproteins from this dsDNA virus play a key role in… Expand
Long-term absolute risk of cervical intraepithelial neoplasia grade 3 or worse following human papillomavirus infection: role of persistence.
- S. K. Kjær, K. Frederiksen, C. Munk, T. Iftner
- Journal of the National Cancer Institute
- 6 October 2010
BACKGROUND Infection with high-risk human papillomavirus (HPV) is the main cause of high-grade cervical intraepithelial neoplasia (CIN) and cancer. It has been suggested that information about… Expand
Identification of a differentiation-inducible promoter in the E7 open reading frame of human papillomavirus type 16 (HPV-16) in raft cultures of a new cell line containing high copy numbers of…
- K. Grassmann, B. Rapp, H. Maschek, K. Petry, T. Iftner
- Biology, Medicine
- Journal of virology
- 1 April 1996
Gene expression of human papillomaviruses (HPV) is tightly linked to differentiation processes within the pluristratified epithelium. To analyze changes in the transcription pattern of HPV-16 during… Expand
Long term predictive values of cytology and human papillomavirus testing in cervical cancer screening: joint European cohort study
Objective To obtain large scale and generalisable data on the long term predictive value of cytology and human papillomavirus (HPV) testing for development of cervical intraepithelial neoplasia grade… Expand
High-Risk Human Papillomaviruses Repress Constitutive Kappa Interferon Transcription via E6 To Prevent Pathogen Recognition Receptor and Antiviral-Gene Expression †
ABSTRACT Persistent infections with human papillomavirus type 16 (HPV16), HPV18, or HPV31 are necessary for the development of cervical cancer, implying that HPVs have evolved immunoevasive… Expand
Inclusion of HPV testing in routine cervical cancer screening for women above 29 years in Germany: results for 8466 patients
In a prospective cohort study 8466 women attending routine cervical cancer screening were recruited. Colposcopy was performed on women with any degree of atypia on cytology and/or a positive… Expand
Population‐based prevalence, type‐ and age‐specific distribution of HPV in women before introduction of an HPV‐vaccination program in Denmark
- Susanne K. Kjær, G. Breugelmans, C. Munk, J. Junge, M. Watson, T. Iftner
- International journal of cancer
- 15 October 2008
Knowledge about the prevalence of human papillomavirus (HPV) on a population level is important. We conducted a large population‐based study in Denmark to determine the overall and age‐specific HPV… Expand
The prevalence of human papillomavirus genotypes in nonmelanoma skin cancers of nonimmunosuppressed individuals identifies high-risk genital types as possible risk factors.
Nonmelanoma skin cancer is the most commonly diagnosed malignant disease in Caucasians. Known risk factors include fair skin, sun exposure, male gender, advancing age, and the presence of solar… Expand
Chapter 12: Human papillomavirus technologies.
Currently, human papillomavirus (HPV) DNA tests validated in large trials and epidemiological studies are the hybrid capture second-generation (HC2) HPV DNA assay and a variety of polymerase chain… Expand