• Publications
  • Influence
5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential.
TLDR
The results suggest that 5-HT2C receptor agonism is associated with therapeutic potential in obsessive compulsive disorder and depression. Expand
A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.
TLDR
These data confirm the notable anxiolytic-like effects observed at low doses with the orphanin FQ/nociceptin neuropeptide given locally into the brain and support a role for orphan in F Q/nOCiceptin in adaptive behavioral fear responses to stress. Expand
Trace Amine-Associated Receptor 1 Modulates Dopaminergic Activity
TLDR
The data reveal Taar1 as regulator of dopaminergic neurotransmission as revealed by enhanced amphetamine-triggered increases in locomotor activity and augmented striatal release of dopamine compared with wild-type animals. Expand
Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress.
TLDR
It is shown that OFQ plays an important role in higher brain functions because it can act as an anxiolytic to attenuate the behavioral inhibition of animals acutely exposed to stressful/anxiogenic environmental conditions. Expand
TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity
TLDR
Modulation of TAar1 activity altered the desensitization rate and agonist potency at 5-HT1A receptors in the dorsal raphe, suggesting that TAAR1 modulates not only dopaminergic but also serotonergic neurotransmission. Expand
RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors
TLDR
RO4938581 is a potent inverse agonist at the GABAA α5 receptor, with both binding and functional selectivity, enhancing hippocampal LTP, and further support the potential of GAB AA α5 receptors as a target for cognition-enhancing drugs. Expand
Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice.
TLDR
OfQ/N appears to be crucially involved in the neurobiological regulation of stress-coping behavior and fear. Expand
A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight
TLDR
TAAR1 agonists may provide a novel and differentiated treatment of schizophrenia as compared with current medication standards, and may improve not only the positive symptoms but also the negative symptoms and cognitive deficits, without causing adverse effects such as motor impairments or weight gain. Expand
Enhanced Long-Term Synaptic Depression in an Animal Model of Depression
TLDR
Long-term synaptic plasticity is an important and ubiquitous form of brain plasticity that is disturbed in an animal model of depression and might impair function and structure of brain circuits involved in the pathophysiology of major depression. Expand
Effect of LSD on Prepulse Inhibition and Spontaneous Behavior in the Rat: A Pharmacological Analysis and Comparison between Two Rat Strains
TLDR
Findings provide empirical evidence to support the view that the hallucinogenic effects of LSD are mediated by a direct agonist effect at 5-HT2A receptors and abolish the locomotor hyperactivity induced by LSD. Expand
...
1
2
3
4
5
...