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RecQ Helicases

Known as: Helicases, RecQ, RecQ Family of DNA Helicases, RecQ Protein 
A family of structurally-related DNA helicases that play an essential role in the maintenance of genome integrity. RecQ helicases were originally… 
National Institutes of Health

Related topics

Related topics

18 relations
Bloom SyndromeIn BloodProcess of secretionRothmund-Thomson syndrome

Narrower (8)

Bloom syndrome proteinDNA helicase RecQLRECQL protein, humanRECQL4 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Site-directed mutants of human RECQ1 reveal functional importance of the zinc binding domain.
2015
2015
RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin.
RecQ helicases are a family of highly conserved proteins that maintain genomic stability through their important roles in… 
Review
2014
Review
2014
The role of RecQ helicases in non-homologous end-joining
Abstract DNA double-strand breaks are highly toxic DNA lesions that cause genomic instability, if not efficiently repaired. RecQ… 
Highly Cited
2013
Highly Cited
2013
Human RECQ1 Interacts with Ku70/80 and Modulates DNA End-Joining of Double-Strand Breaks
Genomic instability is a known precursor to cancer and aging. The RecQ helicases are a highly conserved family of DNA-unwinding… 
Review
2013
Review
2013
Probing Genome Maintenance Functions of human RECQ1
The RecQ helicases are a highly conserved family of DNA-unwinding enzymes that play key roles in protecting the genome stability… 
2011
2011
The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation
BackgroundRecQ helicases play an essential role in the maintenance of genome stability. In humans, loss of RecQ helicase function… 
2008
2008
Bloom's syndrome workshop focuses on the functional specificities of RecQ helicases
2007
2007
Inhibition of DNA helicase, ATPase and DNA-binding activities of E. coli RecQ helicase by chemotherapeutic agents.
RecQ helicases play an essential role in maintaining genetic integrity in all organisms from Escherichia coli to humans. Defects… 
Review
2002
Review
2002
Defending genome integrity during S-phase: putative roles for RecQ helicases and topoisomerase III.
2002
2002
RecQ helicases and genome stability: lessons from model organisms and human disease.
Maintaining the integrity of genetic information is fundamental for the life of a cell and the survival of a species. Cells can… 
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