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RRM1 gene

Known as: Ribonucleotide Reductase M1 Gene, RIBONUCLEOTIDE REDUCTASE, LARGE SUBUNIT, RIBONUCLEOTIDE REDUCTASE, M1 SUBUNIT 
This gene plays a role in the inhibition of cell migration, invasion, and metastasis.
National Institutes of Health

Papers overview

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2013
2013
The aim of this study was to examine the prognostic value of BRCA1, RRM1, and RRM2 in patients with non-small cell lung cancer… Expand
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Highly Cited
2009
Highly Cited
2009
PURPOSE We evaluated the efficacy of gemcitabine versus gemcitabine and carboplatin in patients with advanced non-small-cell lung… Expand
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Highly Cited
2008
Highly Cited
2008
Background Overexpression of RRM1 and RRM2 has been associated with gemcitabine resistance. BRCA1 overexpression increases… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND RRM1, the regulatory subunit of ribonucleotide reductase, is involved in carcinogenesis, tumor progression, and the… Expand
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Highly Cited
2007
Highly Cited
2007
Pancreatic cancer is the most lethal of all solid tumors partially because of its chemoresistance. Although gemcitabine is widely… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Pivotal studies indicate a role of excision repair cross-complementation 1 (ERCC1) gene and ribonucleotide reductase… Expand
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Highly Cited
2006
Highly Cited
2006
PURPOSE RRM1 encodes the regulatory subunit of ribonucleotide reductase and is a molecular target of gemcitabine. Previous… Expand
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Highly Cited
2006
Highly Cited
2006
Objectives Significant variability in the efficacy and toxicity of an anticancer drug is observed in cancer patients. Currently… Expand
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2005
2005
Test-day milk yield records of 11,023 first-parity Holstein cows were used to estimate genetic parameters for milk yield during… Expand
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Highly Cited
2004
Highly Cited
2004
PURPOSE RRM1 has important functions in the determination of the malignant phenotype. It controls cell proliferation through… Expand
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