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Pharmacokinetics of gemcitabine in Chinese patients with non-small-cell lung cancer.
- Lin-run Wang, Ming-zhu Huang, N. Xu, J. Shentu, J. Liu, J. Cai
- Journal of Zhejiang University. Science. B
- 1 May 2005
The hematologic toxicology result showed that the regimen was effective on and tolerated by the patients, and the pharmacokinetic parameters were consistent with those reported in literature. Expand
Phase I study of icotinib hydrochloride (BPI-2009H), an oral EGFR tyrosine kinase inhibitor, in patients with advanced NSCLC and other solid tumors.
Oral icotinib was generally well tolerated, with manageable and reversible adverse events (AEs) and showed positive clinical anti-tumor activities in patients with advanced NSCLC. Expand
Determination of amlodipine in human plasma using automated online solid-phase extraction HPLC-tandem mass spectrometry: application to a bioequivalence study of Chinese volunteers.
- J. Shentu, L. Fu, +4 authors Guo-lan Wu
- Chemistry, Medicine
- Journal of pharmaceutical and biomedical analysis
- 1 November 2012
An automated method (XLC-MS/MS) that uses online solid-phase extraction coupled with HPLC-tandem mass spectrometry was reported here for the first time to quantify amlodipine in human plasma and proved to be less laborious and faster per analysis than offline sample preparation methods. Expand
Determination of risperidone in human plasma by HPLC-MS/MS and its application to a pharmacokinetic study in Chinese volunteers
- Ming-zhu Huang, J. Shentu, Jun-chun Chen, J. Liu, Hui-li Zhou
- Chemistry, Medicine
- Journal of Zhejiang University SCIENCE B
- 1 February 2008
The method was successfully applied to investigate the bioequivalence between two kinds of tablets (test versus reference products) in 18 healthy male Chinese volunteers and the result suggests that two formulations are bioequivalent. Expand
Safety and pharmacokinetics of dicloxacillin in healthy Chinese volunteers following single and multiple oral doses
- Guo-lan Wu, Yunliang Zheng, +6 authors J. Shentu
- Drug design, development and therapy
- 16 October 2015
Dicloxacillin was safe and well tolerated in the volunteers and displayed linear increases in the Cmax and AUC0–10 h values, and no appreciable accumulation of drug occurred with multiple oral doses of dicl Oxacillin. Expand
Simple and Robust Analysis of Cefuroxime in Human Plasma by LC-MS/MS: Application to a Bioequivalence Study
- Xingjiang Hu, Mingzhu Huang, J. Liu, Jun-chun Chen, J. Shentu
- Advances in pharmacological sciences
- 24 April 2014
It was concluded that the two formulations analyzed were bioequivalent in terms of rate and extent of absorption and the method met the principle of quick and easy clinical analysis. Expand
Pharmacokinetic Properties and Tolerability of Cycloserine Following Oral Administration in Healthy Chinese Volunteers: A Randomized, Open-Label, Single- and Multiple-Dose 3-Way Crossover Study.
After multiple doses, the pharmacokinetic properties of cycloserine were consistent with those after single doses, andcycloserine appears to be well tolerated in these healthy volunteers. Expand
Effects of DL111-IT or combined with RU486 on uterine polyamines biosynthesis in rats during early gestation.
The data verified that the decrease in uterine polyamine levels and subsequent decidual cells injuries were the critical role of early pregnancy arrest induced by DL111-IT or RU486. Expand
RRM1 and ERCC1 expression in peripheral blood versus tumor tissue in gemcitabine/carboplatin-treated advanced non-small cell lung cancer
- Guo Bing Zhang, J. Chen, +5 authors J. Shentu
- Biology, Medicine
- Cancer Chemotherapy and Pharmacology
- 3 February 2012
Advanced NSCLC patients with low RRM1 mRNA expression both in peripheral blood and in tumor tissue could benefit from gemcitabine/carboplatin chemotherapy, and Cox multivariate regression analysis showed that ERCC1 expression in tumors tissue was independent indicator for overall survival. Expand
Hemostatic Efficiency and Wound Healing Properties of Natural Zeolite Granules in a Lethal Rabbit Model of Complex Groin Injury
NZG-JY significantly decreases the mortality in a lethal rabbit model of complex groin injury and demonstrates good healing properties, which are significantly less than that in the Quikclot group and the gauze group. Expand