Nucleotide Metabolism

Known as: Nucleotide Synthesis, Nucleotide Metabolic Process, Metabolism, Purines/Pyrimidines/Nucleotides/Nucleic Acids 
The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any… (More)
National Institutes of Health

Related topics

Related topics

50 relations
ADA geneADENOSINE DEAMINASEAPOA1BP protein, humanAPOA1BP wt Allele
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Papers overview

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Highly Cited
2014
Highly Cited
2014
Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells.
Previous work has shown that some cancer cells are highly dependent on serine/glycine uptake for proliferation. Although serine… (More)
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Highly Cited
2013
Highly Cited
2013
Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence.
Oncogene-induced senescence is characterized by a stable cell growth arrest, thus providing a tumor suppression mechanism… (More)
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Highly Cited
2008
Highly Cited
2008
Role of global regulators and nucleotide metabolism in antibiotic tolerance in Escherichia coli.
Bacterial populations produce a small number of persister cells that exhibit multidrug tolerance. Persister cells are largely… (More)
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Highly Cited
2004
Highly Cited
2004
Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism.
Hypoxia is a well-documented inflammatory stimulus and results in tissue polymorphonuclear leukocyte (PMN) accumulation. Likewise… (More)
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Highly Cited
2002
Highly Cited
2002
Reaction routes in biochemical reaction systems: algebraic properties, validated calculation procedure and example from nucleotide metabolism.
Elementary flux modes (direct reaction routes) are minimal sets of enzymes that can operate at steady state, with all… (More)
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Highly Cited
2001
Highly Cited
2001
The white spot syndrome virus DNA genome sequence.
White spot syndrome virus (WSSV) is at present a major scourge to worldwide shrimp cultivation. We have determined the entire… (More)
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Highly Cited
1998
Highly Cited
1998
RNA-catalysed nucleotide synthesis
The ‘RNA world’ hypothesis proposes that early life developed by making use of RNA molecules, rather than proteins, to catalyse… (More)
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Highly Cited
1997
Highly Cited
1997
The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes.
In an effort to discover novel oligonucleotide modifications for antisense therapeutics, we have prepared… (More)
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Review
1985
Review
1985
Nucleotide metabolism and cellular damage in myocardial ischemia.
Adenine nucleotide metabolism is greatly altered by myocardial anoxia or ischemia, both of which induce depletion of ATP and of… (More)
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Highly Cited
1982
Highly Cited
1982
Prolonged myocardial nucleotide depletion after brief ischemia in the open-chest dog.
Purine and pyrimidine nucleotides are essential energy sources for basic metabolic reactions and play important roles in protein… (More)
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