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The influence of gemcitabine pathway polymorphisms on treatment outcome in patients with malignant mesothelioma
Objective Identification of biomarkers that could predict gemcitabine efficacy and toxicity is a key issue in the development of individualized therapy. The aim of our study was to evaluate theExpand
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Asbestosis and Catalase Genetic Polymorphism
Asbestosis and Catalase Genetic Polymorphism Catalase (CAT) is part of the enzymatic defense system against reactive oxygen species (ROS), known to be involved in the pathogenesis of asbestosis. ThisExpand
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Glutathione S-Transferases GSTM1 and GSTT1 Polymorphisms and Asbestosis
Objective: In a nested case-control study, the authors investigated whether the deletion polymorphism of glutathione S-transferases GSTM1 and GSTT1 represents a risk factor for the development ofExpand
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Detection of surgical glove integrity.
Surgical glove integrity is essential for universal precautions; glove safety is verified by the water load test (WLT). Concerns regarding glove injury have prompted newer testing methodologies,Expand
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Long-term effects of elemental mercury on renal function in miners of the Idrija Mercury Mine.
BACKGROUND The kidneys are one of the main target organs for elemental mercury (Hg(0)). The influence of Hg(0) on kidneys has been extensively studied but the long-term effects on this organ have notExpand
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DNA Repair Polymorphisms and Treatment Outcomes of Patients with Malignant Mesothelioma Treated with Gemcitabine-Platinum Combination Chemotherapy
Introduction: Genetic polymorphisms that affect DNA repair capacity can modulate the efficacy and toxicity of cytotoxic agents. Therefore, the aim of our study was to evaluate the influence ofExpand
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Comparative study on the effect of phosphorylated TCR zeta chain ITAM sequences on early activation events in Jurkat T cells.
One of the main dilemma in T cell receptor (TCR) signal transduction is whether the presence of multiple Immunoreceptor Tyrosine-based Activation Motifs (ITAMs) within the TCR signaling module servesExpand
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Soluble Mesothelin-Related Peptides Levels in Patients with Malignant Mesothelioma
Soluble mesothelin-related peptides (SMRP) are a potential tumor marker for malignant mesothelioma. The aim of this study was to determine the differences in SMRP levels in patients with malignantExpand
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Manganese and Extracellular Superoxide Dismutase Polymorphisms and Risk for Asbestosis
Manganese and extracellular superoxide dismutases (SOD2 and SOD3) are part of the enzymatic defence against reactive oxygen species, which are involved in the pathogenesis of asbestosis. This studyExpand
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Fibulin-3 as a biomarker of response to treatment in malignant mesothelioma
Abstract Background. Fibulin-3 is a new potential biomarker for malignant mesothelioma (MM). This study evaluated the potential applicability of fibulin-3 plasma levels as a biomarker of response toExpand
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