FAQ

RNA Interference

Known as: RNA interference (RNAi), Quelling, RNA Silencing 
The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or… (More)

Topic mentions per year

Topic mentions per year

1938-2017
01000200019382016

Related topics

Related topics

38 relations
AGO1 geneAGO2 geneAGO3 geneAGO4 gene
(More)

Broader (2)

Genetic TechniquesRNA

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
RNA Interference
physiological aspects
RNA, Small Interfering
RNA
RNA-Induced Silencing Complex
cyclooxygenase 2

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Rational siRNA design for RNA interference
Short-interfering RNAs suppress gene expression through a highly regulated enzyme-mediated process called RNA interference (RNAi… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
Is this relevant?
Highly Cited
2003
Highly Cited
2003
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
RNA interference (RNAi) has recently emerged as a specific and efficient method to silence gene expression in mammalian cells… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?
Highly Cited
2002
Highly Cited
2002
RNA interference in adult mice.
RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Role for a bidentate ribonuclease in the initiation step of RNA interference.
RNA interference (RNAi) is the mechanism through which double-stranded RNAs silence cognate genes. In plants, this can occur at… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2001
Highly Cited
2001
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA.
The 21-nucleotide small temporal RNA (stRNA) let-7 regulates developmental timing in Caenorhabditis elegans and probably in other… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2001
Highly Cited
2001
RNA interference is mediated by 21- and 22-nucleotide RNAs.
Double-stranded RNA (dsRNA) induces sequence-specific posttranscriptional gene silencing in many organisms by a process known as… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 6
  • figure 7
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans.
Double-stranded RNAs can suppress expression of homologous genes through an evolutionarily conserved process named RNA… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing
RNAi is a gene-silencing phenomenon triggered by double-stranded (ds) RNA and involves the generation of 21 to 26 nt RNA segments… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference.
Complete genomic sequence is known for two multicellular eukaryotes, the nematode Caenorhabditis elegans and the fruit fly… (More)
  • table 1
  • table 2
  • table 3
  • figure 2
  • figure 1
Is this relevant?
Highly Cited
2000
Highly Cited
2000
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells.
In a diverse group of organisms that includes Caenorhabditis elegans, Drosophila, planaria, hydra, trypanosomes, fungi and plants… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?