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RNA Interference

Known as: RNA interference (RNAi), Quelling, RNA Silencing 
The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or… 
National Institutes of Health

Related topics

Related topics

43 relations
AGO1 geneAGO2 geneAGO3 geneAGO4 gene

Broader (2)

Genetic TechniquesRNA

Narrower (2)

negative regulation of translation involved in RNA interferencesiRNA loading onto RISC involved in RNA interference

Papers overview

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Highly Cited
2009
Highly Cited
2009
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard… 
Highly Cited
2007
Highly Cited
2007
Control of coleopteran insect pests through RNA interference
Commercial biotechnology solutions for controlling lepidopteran and coleopteran insect pests on crops depend on the expression of… 
Highly Cited
2004
Highly Cited
2004
Rational siRNA design for RNA interference
Short-interfering RNAs suppress gene expression through a highly regulated enzyme-mediated process called RNA interference (RNAi… 
Highly Cited
2003
Highly Cited
2003
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
RNA interference (RNAi) has recently emerged as a specific and efficient method to silence gene expression in mammalian cells… 
Highly Cited
2002
Highly Cited
2002
RNA interference : RNA
A conserved biological response to double-stranded RNA, known variously as RNA interference (RNAi) or post-transcriptional gene… 
Highly Cited
2001
Highly Cited
2001
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
RNA interference (RNAi) is the process of sequence-specific, post-transcriptional gene silencing in animals and plants, initiated… 
Highly Cited
2001
Highly Cited
2001
Role for a bidentate ribonuclease in the initiation step of RNA interference
RNA interference (RNAi) is the mechanism through which double-stranded RNAs silence cognate genes. In plants, this can occur at… 
Highly Cited
2001
Highly Cited
2001
RNA interference is mediated by 21- and 22-nucleotide RNAs.
Double-stranded RNA (dsRNA) induces sequence-specific posttranscriptional gene silencing in many organisms by a process known as… 
Highly Cited
2001
Highly Cited
2001
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans.
Double-stranded RNAs can suppress expression of homologous genes through an evolutionarily conserved process named RNA… 
Highly Cited
2000
Highly Cited
2000
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
Complete genomic sequence is known for two multicellular eukaryotes, the nematode Caenorhabditis elegans and the fruit fly… 
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