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RNA Interference
Known as:
RNA interference (RNAi)
, Quelling
, RNA Silencing
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The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or…
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National Institutes of Health
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Related topics
Related topics
43 relations
AGO1 gene
AGO2 gene
AGO3 gene
AGO4 gene
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Broader (2)
Genetic Techniques
RNA
Narrower (2)
negative regulation of translation involved in RNA interference
siRNA loading onto RISC involved in RNA interference
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
D. Barbie
,
P. Tamayo
,
+32 authors
W. Hahn
Nature
2009
Corpus ID: 4415321
The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard…
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Highly Cited
2007
Highly Cited
2007
Control of coleopteran insect pests through RNA interference
J. Baum
,
T. Bogaert
,
+9 authors
James K. Roberts
Nature Biotechnology
2007
Corpus ID: 13856714
Commercial biotechnology solutions for controlling lepidopteran and coleopteran insect pests on crops depend on the expression of…
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Highly Cited
2004
Highly Cited
2004
Rational siRNA design for RNA interference
A. Reynolds
,
D. Leake
,
Q. Boese
,
S. Scaringe
,
W. Marshall
,
A. Khvorova
Nature Biotechnology
2004
Corpus ID: 10041179
Short-interfering RNAs suppress gene expression through a highly regulated enzyme-mediated process called RNA interference (RNAi…
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Highly Cited
2003
Highly Cited
2003
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
D. Rubinson
,
C. Dillon
,
+10 authors
L. Parijs
Nature Genetics
2003
Corpus ID: 781082
RNA interference (RNAi) has recently emerged as a specific and efficient method to silence gene expression in mammalian cells…
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Highly Cited
2002
Highly Cited
2002
RNA interference : RNA
G. Hannon
2002
Corpus ID: 89279797
A conserved biological response to double-stranded RNA, known variously as RNA interference (RNAi) or post-transcriptional gene…
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Highly Cited
2001
Highly Cited
2001
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
S. Elbashir
,
J. Harborth
,
W. Lendeckel
,
A. Yalçin
,
K. Weber
,
T. Tuschl
Nature
2001
Corpus ID: 710341
RNA interference (RNAi) is the process of sequence-specific, post-transcriptional gene silencing in animals and plants, initiated…
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Highly Cited
2001
Highly Cited
2001
Role for a bidentate ribonuclease in the initiation step of RNA interference
E. Bernstein
,
A. Caudy
,
S. Hammond
,
G. Hannon
Nature
2001
Corpus ID: 4371481
RNA interference (RNAi) is the mechanism through which double-stranded RNAs silence cognate genes. In plants, this can occur at…
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Highly Cited
2001
Highly Cited
2001
RNA interference is mediated by 21- and 22-nucleotide RNAs.
S. Elbashir
,
W. Lendeckel
,
T. Tuschl
Genes & Development
2001
Corpus ID: 6567101
Double-stranded RNA (dsRNA) induces sequence-specific posttranscriptional gene silencing in many organisms by a process known as…
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Highly Cited
2001
Highly Cited
2001
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans.
R. Ketting
,
S. Fischer
,
E. Bernstein
,
T. Sijen
,
G. Hannon
,
R. Plasterk
Genes & Development
2001
Corpus ID: 665466
Double-stranded RNAs can suppress expression of homologous genes through an evolutionarily conserved process named RNA…
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Highly Cited
2000
Highly Cited
2000
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
A. Fraser
,
R. Kamath
,
Peder Zipperlen
,
M. Martinez-Campos
,
M. Sohrmann
,
J. Ahringer
Nature
2000
Corpus ID: 4373444
Complete genomic sequence is known for two multicellular eukaryotes, the nematode Caenorhabditis elegans and the fruit fly…
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