AGO1 gene

Known as: EUKARYOTIC TRANSLATION INITIATION FACTOR 2C, SUBUNIT 1, AGO1, argonaute 1 
This gene is involved in RNA binding and gene silencing.
National Institutes of Health

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11 relations
AGO2 geneAGO3 geneAGO4 geneEIF2S1 gene
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EIF2C1 wt Allele

Papers overview

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Highly Cited
2008
Highly Cited
2008
MicroRNA-directed transcriptional gene silencing in mammalian cells.
MicroRNAs (miRNAs) regulate gene expression at the posttranscriptional level in the cytoplasm, but recent findings suggest… (More)
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Highly Cited
2008
Highly Cited
2008
Arabidopsis DRB4, AGO1, AGO7, and RDR6 participate in a DCL4-initiated antiviral RNA silencing pathway negatively regulated by DCL1.
Plant RNA silencing machinery enlists four primary classes of proteins to achieve sequence-specific regulation of gene expression… (More)
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Highly Cited
2008
Highly Cited
2008
AGO1-miR173 complex initiates phased siRNA formation in plants.
MicroRNA (miRNA)-guided cleavage initiates entry of primary transcripts into the transacting siRNA (tasiRNA) biogenesis pathway… (More)
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Highly Cited
2006
Highly Cited
2006
AGO1 homeostasis entails coexpression of MIR168 and AGO1 and preferential stabilization of miR168 by AGO1.
Arabidopsis ARGONAUTE1 (AGO1) encodes the RNA slicer enzyme of the microRNA (miRNA) pathway and is regulated by miR168-programmed… (More)
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Highly Cited
2006
Highly Cited
2006
Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells
Argonaute proteins are the core components of effector complexes that facilitate RNA interference (RNAi). Small interfering RNAs… (More)
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Highly Cited
2004
Highly Cited
2004
The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development.
MicroRNAs (miRNAs) are endogenous 21-24-nt RNAs that can down-regulate gene expression by pairing to the messages of protein… (More)
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Highly Cited
2004
Highly Cited
2004
RNAi-mediated targeting of heterochromatin by the RITS complex.
RNA interference (RNAi) is a widespread silencing mechanism that acts at both the posttranscriptional and transcriptional levels… (More)
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Highly Cited
2004
Highly Cited
2004
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.
Argonaute proteins associate with small RNAs that guide mRNA degradation, translational repression, or a combination of both. The… (More)
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Highly Cited
2000
Highly Cited
2000
AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals.
Introduction of transgene DNA may lead to specific degradation of RNAs that are homologous to the transgene transcribed sequence… (More)
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Highly Cited
1998
Highly Cited
1998
AGO1 defines a novel locus of Arabidopsis controlling leaf development.
An allelic series of the novel argonaute mutant (ago1-1 to ago1-6) of the herbaceous plant Arabidopsis thaliana has been isolated… (More)
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