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AGO1 gene

Known as: EUKARYOTIC TRANSLATION INITIATION FACTOR 2C, SUBUNIT 1, AGO1, argonaute 1 
This gene is involved in RNA binding and gene silencing.
National Institutes of Health

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Related topics

11 relations
AGO2 geneAGO3 geneAGO4 geneEIF2S1 gene
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EIF2C1 wt Allele

Papers overview

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Highly Cited
2010
Highly Cited
2010
The Science of Stroke: Mechanisms in Search of Treatments
Dieter Edbauer,1,4,* Joel R. Neilson,2 Kelly A. Foster,1 Chi-Fong Wang,1 Daniel P. Seeburg,1 Matthew N. Batterton,1 Tomoko Tada,1… Expand
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Highly Cited
2008
Highly Cited
2008
MicroRNA-directed transcriptional gene silencing in mammalian cells
MicroRNAs (miRNAs) regulate gene expression at the posttranscriptional level in the cytoplasm, but recent findings suggest… Expand
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Highly Cited
2006
Highly Cited
2006
AGO1 homeostasis entails coexpression of MIR168 and AGO1 and preferential stabilization of miR168 by AGO1.
Arabidopsis ARGONAUTE1 (AGO1) encodes the RNA slicer enzyme of the microRNA (miRNA) pathway and is regulated by miR168-programmed… Expand
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Highly Cited
2005
Highly Cited
2005
Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies
RNA interference (RNAi) is an important means of eliminating mRNAs, but the intracellular location of RNA-induced silencing… Expand
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Highly Cited
2004
Highly Cited
2004
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.
Argonaute proteins associate with small RNAs that guide mRNA degradation, translational repression, or a combination of both. The… Expand
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Highly Cited
2004
Highly Cited
2004
Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway
Fragile X syndrome is caused by a loss of expression of the fragile X mental retardation protein (FMRP). FMRP is a selective RNA… Expand
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Highly Cited
2004
Highly Cited
2004
RNAi-Mediated Targeting of Heterochromatin by the RITS Complex
RNA interference (RNAi) is a widespread silencing mechanism that acts at both the posttranscriptional and transcriptional levels… Expand
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Highly Cited
2004
Highly Cited
2004
Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways.
In mammalian cells, both microRNAs (miRNAs) and small interfering RNAs (siRNAs) are thought to be loaded into the same RNA… Expand
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Highly Cited
2000
Highly Cited
2000
AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals.
Introduction of transgene DNA may lead to specific degradation of RNAs that are homologous to the transgene transcribed sequence… Expand
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Highly Cited
1998
Highly Cited
1998
AGO1 defines a novel locus of Arabidopsis controlling leaf development
An allelic series of the novel argonaute mutant (ago1‐1 to ago1‐6) of the herbaceous plant Arabidopsis thaliana has been isolated… Expand
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