The structure and repertoire of small interfering RNAs in Leishmania (Viannia) braziliensis reveal diversification in the trypanosomatid RNAi pathway.

@article{Atayde2013TheSA,
  title={The structure and repertoire of small interfering RNAs in Leishmania (Viannia) braziliensis reveal diversification in the trypanosomatid RNAi pathway.},
  author={Vanessa Diniz Atayde and Huafang Shi and Joseph B. Franklin and Nicholas Carriero and Timothy Notton and L F Lye and Katherine M. B. Owens and Stephen M Beverley and Christian Tschudi and Elisabetta Ullu},
  journal={Molecular microbiology},
  year={2013},
  volume={87 3},
  pages={580-93}
}
Among trypanosomatid protozoa the mechanism of RNA interference (RNAi) has been investigated in Trypanosoma brucei and to a lesser extent in Leishmania braziliensis. Although these two parasitic organisms belong to the same family, they are evolutionarily distantly related raising questions about the conservation of the RNAi pathway. Here we carried out an in-depth analysis of small interfering RNAs (siRNAs) associated with L. braziliensis Argonaute1 (LbrAGO1). In contrast to T. brucei… CONTINUE READING

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