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RHOK protein, human

Known as: G protein-coupled receptor kinase 1, human, GRK1 protein, human, GPRK1 protein, human 
Rhodopsin kinase (563 aa, ~64 kDa) is encoded by the human GRK1 gene. This protein plays a role in the regulation of rhodopsin signaling.
National Institutes of Health

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12 relations
Enzyme GeneG Protein-Coupled Receptor SignalingGRK1 geneGRK1 wt Allele

Broader (1)

rhodopsin kinase

Papers overview

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2008
2008
Amino Acid Residues in GRK1/GRK7 Responsible for Interaction with S‐Modulin/Recoverin †
GRK1 is a visual pigment kinase in rods and is essential for inactivation of light‐activated rhodopsin. The GRK1 activity is… 
2006
2006
Ca2+‐dependent conformational changes in the neuronal Ca2+‐sensor recoverin probed by the fluorescent dye Alexa647
Recoverin belongs to the superfamily of EF‐hand Ca2+‐binding proteins and operates as a Ca2+‐sensor in vertebrate photoreceptor… 
2006
2006
Differential phosphorylation of the rhodopsin cytoplasmic tail mediates the binding of arrestin and its splice variant, p44.
Deactivation of the vertebrate photopigment rhodopsin is achieved through a two-step process. Rhodopsin is first phosphorylated… 
2001
2001
Probing the dark state tertiary structure in the cytoplasmic domain of rhodopsin: proximities between amino acids deduced from spontaneous disulfide bond formation between Cys316 and engineered…
A dark state tertiary structure in the cytoplasmic domain of rhodopsin is presumed to be the key to the restriction of binding of… 
2001
2001
cDNA cloning and characterization of a novel squid rhodopsin kinase encoding multiple modular domains
Rhodopsin phosphorylation is one of the key mechanisms of inactivation in vertebrate and invertebrate visual signal transduction… 
1999
1999
The Amino Terminus with a Conserved Glutamic Acid of G Protein‐Coupled Receptor Kinases Is Indispensable for Their Ability to Phosphorylate Photoactivated Rhodopsin
Abstract : To investigate functions of the consensus amino terminus of G protein‐coupled receptor kinases (GRKs), two amino… 
1999
1999
Alternative splicing produces transcripts encoding four variants of mouse G-protein-coupled receptor kinase 6.
A family of protein kinases, termed G-protein-coupled receptor kinases (GRK1-6), is known to phosphorylate agonist-occupied G… 
1996
1996
Zinc causes an apparent increase in rhodopsin phosphorylation.
PURPOSE Rhodopsin is a zinc-binding protein. We investigated the effect of low concentrations of zinc on the initial… 
Highly Cited
1993
Highly Cited
1993
Cooperativity during multiple phosphorylations catalyzed by rhodopsin kinase: supporting evidence using synthetic phosphopeptides.
Rhodopsin kinase is a key component in the shutdown of visual transduction. The phosphorylation of rhodopsin's C-terminus was… 
1990
1990
Nucleoside inhibitors of rhodopsin kinase.
The specificity of the ATP-binding site of rhodopsin kinase was studied with adenosine analogues that are competitive inhibitors… 
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