P. Hargrave

Publications156
h-index48
Citations7,962
Highly Influential Citations192
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Anti-rhodopsin monoclonal antibodies of defined specificity: Characterization and application
Rhodopsin C terminus, the site of mutations causing retinal disease, regulates trafficking by binding to ADP-ribosylation factor 4 (ARF4).
TLDR
It is reported that this sorting motif binds specifically to the small GTPase ARF4, a member of the ARF family of membrane budding and protein sorting regulators, which was essential for the generation of post-Golgi carriers targeted to the rod outer segments of retinal photoreceptors.
Site of G protein binding to rhodopsin mapped with synthetic peptides from the alpha subunit.
The interaction between receptors and guanine nucleotide binding (G) proteins leads to G protein activation and subsequent regulation of effector enzymes. The molecular basis of receptor-G protein…
Three cytoplasmic loops of rhodopsin interact with transducin.
TLDR
The sites of interaction of rhodopsin with its G protein are mapped, which by analogy suggests how other members of this class of receptors may interact with their G proteins.
Localization of binding sites for carboxyl terminal specific anti-rhodopsin monoclonal antibodies using synthetic peptides.
TLDR
Cleavage of the seven amino acid C-terminus from rhodopsin and further cleavage to F1 and F2 fragments with Staphylococcus aureus V8 protease abolished binding of rho 1D4 antibody to the membrane-bound rhodopin fragments.
Arrangement of rhodopsin transmembrane α-helices
Rhodopsins, the photoreceptors in rod cells, are G-protein-coupled receptors with seven hydrophobic segments containing characteristic conserved sequence patterns that define a large family,. Members…
Regulation of sorting and post-Golgi trafficking of rhodopsin by its C-terminal sequence QVS(A)PA.
TLDR
Synthetic peptides used as competitive inhibitors of rhodopsin trafficking in the frog retinal cell-free system suggest that the amino acids QVS(A)PA comprise a signal that is recognized by specific factors in the trans-Golgi network.
Arrangement of rhodopsin transmembrane alpha-helices.
Rhodopsins, the photoreceptors in rod cells, are G-protein-coupled receptors with seven hydrophobic segments containing characteristic conserved sequence patterns that define a large family. Members…
Structural prediction of membrane-bound proteins.
A prediction algorithm based on physical characteristics of the twenty amino acids and refined by comparison to the proposed bacteriorhodopsin structure was devised to delineate likely…
The occurrence of serum autoantibodies against enolase in cancer-associated retinopathy.
TLDR
This is the first report of the presence of serum antibodies to retinal enolase in the patients with cancer and the CAR syndrome, and the significance of these antibodies for the disease process is under investigation.
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