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Mutations in Rpe65 disrupt synthesis of the opsin chromophore ligand 11-cis-retinal and cause Leber congenital amaurosis (LCA), a… Expand Phosphorylation is thought to be an essential first step in the prompt deactivation of photoexcited rhodopsin. In vitro, the… Expand Rhodopsin phosphorylation is a key event in the deactivation of this G-protein-coupled receptor. Rhodopsin kinase mediates the… Expand Rhodopsin is the photoreceptor protein in rod cells of the vertebrate retina and the first member of the class of G protein… Expand The primary structure of bovine rhodopsin kinase (RK), which phosphorylates light-activated rhodopsin (Rho*), terminates with the… Expand We have shown by intravitreal injection of [3H]mevalonolactone that a 65 kDa protein in rat photoreceptors is posttranslationally… Expand Rhodopsin kinase (RK) catalyzes the phosphorylation of rhodopsin (Rho) as one of the steps in quenching photoactivated Rho. In… Expand Light-dependent deactivation of rhodopsin as well as homologous desensitization of beta-adrenergic receptors involves receptor… Expand Rhodopsin kinase was purified to near homogeneity by affinity binding to light-exposed rod cell outer segment membranes, followed… Expand The structural components involved in transduction of extracellular signals as diverse as a photon of light impinging on the… Expand