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Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function
TLDR
Observations indicate that CaBP4 is important for normal synaptic function, probably through regulation of Ca2+ influx and neurotransmitter release in photoreceptor synaptic terminals. Expand
Lecithin-retinol Acyltransferase Is Essential for Accumulation of All-trans-Retinyl Esters in the Eye and in the Liver*
TLDR
The histological analysis and electron microscopy of the retina for 6–8-week-old Lrat-/- mice revealed that the rod outer segments are ∼35% shorter than those of Lrat+/+ mice, whereas other neuronal layers appear normal andScotopic and photopic electroretinograms as well as pupillary constriction analyses revealed that rod and cone visual functions are severely attenuated at an early age. Expand
Dual-substrate Specificity Short Chain Retinol Dehydrogenases from the Vertebrate Retina* 210
TLDR
Three enzymes from a novel subfamily of four retinol dehydrogenases (RDH11–14) that display dual-substrate specificity are described, uniquely metabolizing all-trans- andcis-retinols with C15 pro-Rspecificity. Expand
RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome.
TLDR
Evidence is provided that, in the absence of Stra6, holo-Rbp4 provokes nonspecific vitamin A excess in several embryonic tissues, impairing retinoic acid receptor signaling and gene regulation. Expand
A novel subtype of G‐protein‐coupled receptor kinase, GRK7, in teleost cone photoreceptors
TLDR
The isolated retinal cDNA fragments encoding the putative G‐protein‐coupled receptor kinases (GRKs) were isolated from medaka are consistent with the concept that lower vertebrates have rod‐ and cone‐specific opsin kinases. Expand
Retinol Dehydrogenase (RDH12) Protects Photoreceptors from Light-induced Degeneration in Mice*
TLDR
It is shown that RDH12 localizes to the photoreceptor inner segments and that deletion of this gene in mice slows the kinetics of all-trans-retinal reduction, delaying dark adaptation, and severe visual impairments of individuals with null mutations in RDH 12 may likely be caused by light damage. Expand
Calcium-binding proteins: intracellular sensors from the calmodulin superfamily.
TLDR
The expansion of the CaM-like protein family reveals diversification among Ca(2+)-binding proteins that evolved on the basis of the classic molecule, CaM, that display similarities to calmodulin (CaM). Expand
Rhodopsin phosphorylation: 30 years later
TLDR
A summary of the current understanding of rhodopsin phosphorylation and the properties of r Rhodopsin kinase is presented, along with some expectations of future investigations into these topics. Expand
An Unconventional Secretory Pathway Mediates the Cilia Targeting of Peripherin/rds
TLDR
Evidence is provided that P/rds is targeted to the cilia by an unconventional secretion pathway, which suggests that both conventional secretion and unconventional secretion need to cooperate for the renewal of the photoreceptor sensory cilium. Expand
Role of Photoreceptor-specific Retinol Dehydrogenase in the Retinoid Cycle in Vivo*
TLDR
It is concluded that prRDH is an enzyme that catalyzes reduction of all-trans-retinal in the rod outer segment, most noticeably at higher light intensities and prolonged illumination, but is not an essential enzyme of the retinoid cycle. Expand
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