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RAF1 gene
Known as:
TRANSFORMING REPLICATION-DEFECTIVE MURINE RETROVIRUS 3611-MSV
, V-RAF-1 MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1
, C-Raf proto-oncogene, serine/threonine kinase
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This gene is involved in cell growth, proliferation, differentiation and migration. It also plays a role in apoptosis.
National Institutes of Health
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Related topics
Related topics
14 relations
Cell Cycle Control
MAP Kinase Kinase Kinase 1
MAP kinase kinase activity
MAP3K1 gene
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RAF1 wt Allele
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
p21-activated Kinase 1 (Pak1)-dependent Phosphorylation of Raf-1 Regulates Its Mitochondrial Localization, Phosphorylation of BAD, and Bcl-2 Association*
Shenghao Jin
,
Y. Zhuo
,
Wei-Ren Guo
,
J. Field
Journal of Biological Chemistry
2005
Corpus ID: 46637569
Raf-1 protects cells from apoptosis, independently of its signals to MEK and ERK, by translocating to the mitochondria where it…
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Highly Cited
2002
Highly Cited
2002
Raf-1 Antagonizes Erythroid Differentiation by Restraining Caspase Activation
A. Kolbus
,
Sandra Pilat
,
+4 authors
M. Baccarini
Journal of Experimental Medicine
2002
Corpus ID: 327942
The Raf kinases are key signal transducers activated by mitogens or oncogenes. The best studied Raf isoform, Raf-1, was…
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Highly Cited
2001
Highly Cited
2001
S338 Phosphorylation of Raf-1 Is Independent of Phosphatidylinositol 3-Kinase and Pak3
A. Chiloeches
,
C. Mason
,
R. Marais
Molecular and Cellular Biology
2001
Corpus ID: 23370889
ABSTRACT The Raf-1 serine/threonine protein kinase requires phosphorylation of the serine at position 338 (S338) for activation…
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Highly Cited
1999
Highly Cited
1999
The Raf-1/MEK/ERK Pathway Regulates the Expression of the p21Cip1/Waf1 Gene in Chondrocytes*
F. Beier
,
Allison C. Taylor
,
P. Luvalle
Journal of Biological Chemistry
1999
Corpus ID: 41313431
The gene encoding the cyclin-dependent kinase inhibitor p21Cip1/Waf1 is up-regulated in many differentiating cells, including…
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Highly Cited
1997
Highly Cited
1997
Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway
L. Stancato
,
Minoru Sakatsume
,
+11 authors
A. Larner
Molecular and Cellular Biology
1997
Corpus ID: 17758676
Activation of early response genes by interferons (IFNs) and other cytokines requires tyrosine phosphorylation of a family of…
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Highly Cited
1994
Highly Cited
1994
The post-translational modification of ras p21 is important for Raf-1 activation.
Akira Kikuchi
,
Lewis T. Williams
Journal of Biological Chemistry
1994
Corpus ID: 28000139
Highly Cited
1993
Highly Cited
1993
GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells.
Hiroshi Koide
,
T. Satoh
,
Masato Nakafuku
,
Yoshito Kaziro
Proceedings of the National Academy of Sciences…
1993
Corpus ID: 8493071
Ras is involved in signal transduction of various factors for growth, differentiation, and oncogenesis. Recent studies have…
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Highly Cited
1993
Highly Cited
1993
Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase.
N. Williams
,
H. Paradis
,
S. Agarwal
,
D. Charest
,
S. Pelech
,
T. Roberts
Proceedings of the National Academy of Sciences…
1993
Corpus ID: 34432559
Mitogen-activated protein (MAP) kinases Raf-1, pp60src, and p21ras all play important roles in the transfer of signals from the…
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Highly Cited
1991
Highly Cited
1991
Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor-dependent myeloid cell line.
Y. Kanakura
,
B. Druker
,
+4 authors
J. Griffin
Blood
1991
Corpus ID: 24233056
The product of the c-raf-1 proto-oncogene, Raf-1, is a 74,000-dalton cytoplasmic serine/threonine protein kinase that has been…
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Highly Cited
1991
Highly Cited
1991
Interleukin-2-triggered Raf-1 expression, phosphorylation, and associated kinase activity increase through G1 and S in CD3-stimulated primary human T cells
A. Zmuidzinas
,
H. Mamon
,
T. Roberts
,
K. Smith
Molecular and Cellular Biology
1991
Corpus ID: 19653152
To gain further insight into the role of Raf-1 in normal cell growth, c-raf-1 mRNA expression, Raf-1 protein production, and Raf…
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