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RAF1 gene

Known as: TRANSFORMING REPLICATION-DEFECTIVE MURINE RETROVIRUS 3611-MSV, V-RAF-1 MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1, C-Raf proto-oncogene, serine/threonine kinase 
This gene is involved in cell growth, proliferation, differentiation and migration. It also plays a role in apoptosis.
National Institutes of Health

Related topics

Related topics

14 relations
Cell Cycle ControlMAP Kinase Kinase Kinase 1MAP kinase kinase activityMAP3K1 gene

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RAF1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Mammalian Ste20-like Kinase (Mst2) Indirectly Supports Raf-1/ERK Pathway Activity via Maintenance of Protein Phosphatase-2A Catalytic Subunit Levels and Consequent Suppression of Inhibitory Raf-1…
Many tumor suppressor proteins act to blunt the effects of mitogenic signaling pathways. Loss of function mutations in the merlin… 
Highly Cited
2005
Highly Cited
2005
p21-activated Kinase 1 (Pak1)-dependent Phosphorylation of Raf-1 Regulates Its Mitochondrial Localization, Phosphorylation of BAD, and Bcl-2 Association*
Raf-1 protects cells from apoptosis, independently of its signals to MEK and ERK, by translocating to the mitochondria where it… 
Highly Cited
2002
Highly Cited
2002
Raf-1 Antagonizes Erythroid Differentiation by Restraining Caspase Activation
The Raf kinases are key signal transducers activated by mitogens or oncogenes. The best studied Raf isoform, Raf-1, was… 
Highly Cited
2001
Highly Cited
2001
S338 Phosphorylation of Raf-1 Is Independent of Phosphatidylinositol 3-Kinase and Pak3
ABSTRACT The Raf-1 serine/threonine protein kinase requires phosphorylation of the serine at position 338 (S338) for activation… 
Highly Cited
1999
Highly Cited
1999
The Raf-1/MEK/ERK Pathway Regulates the Expression of the p21Cip1/Waf1 Gene in Chondrocytes*
The gene encoding the cyclin-dependent kinase inhibitor p21Cip1/Waf1 is up-regulated in many differentiating cells, including… 
Highly Cited
1997
Highly Cited
1997
Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway
Activation of early response genes by interferons (IFNs) and other cytokines requires tyrosine phosphorylation of a family of… 
Highly Cited
1994
Highly Cited
1994
The post-translational modification of ras p21 is important for Raf-1 activation.
Highly Cited
1993
Highly Cited
1993
GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells.
Ras is involved in signal transduction of various factors for growth, differentiation, and oncogenesis. Recent studies have… 
Highly Cited
1991
Highly Cited
1991
Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor-dependent myeloid cell line.
The product of the c-raf-1 proto-oncogene, Raf-1, is a 74,000-dalton cytoplasmic serine/threonine protein kinase that has been… 
Highly Cited
1991
Highly Cited
1991
Interleukin-2-triggered Raf-1 expression, phosphorylation, and associated kinase activity increase through G1 and S in CD3-stimulated primary human T cells
To gain further insight into the role of Raf-1 in normal cell growth, c-raf-1 mRNA expression, Raf-1 protein production, and Raf… 
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