RAF1 gene

Known as: TRANSFORMING REPLICATION-DEFECTIVE MURINE RETROVIRUS 3611-MSV, V-RAF-1 MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1, C-Raf proto-oncogene, serine/threonine kinase 
This gene is involved in cell growth, proliferation, differentiation and migration. It also plays a role in apoptosis.
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Raf-1 protects cells from apoptosis, independently of its signals to MEK and ERK, by translocating to the mitochondria where it… (More)
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Highly Cited
1999
Highly Cited
1999
Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase… (More)
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Highly Cited
1998
Highly Cited
1998
Vascular endothelial growth factor (VEGF) is an endothelium-specific, secreted protein that acts as a vasodilator, angiogenic… (More)
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Highly Cited
1998
Highly Cited
1998
The oncogenic protein Bcl-2 functions as a potent inhibitor of programmed cell death. This survival activity has been shown in… (More)
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Highly Cited
1997
Highly Cited
1997
Activation of the Raf serine/threonine protein kinases is tightly regulated by multiple phosphorylation events. Phosphorylation… (More)
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Highly Cited
1996
Highly Cited
1996
c-Raf-1 (Raf-1) is a central component of signal transduction pathways stimulated by various growth factors, protein kinase C… (More)
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1996
1996
The serine/threonine protein kinase Raf-1 is a component of a conserved intracellular signaling cascade that controls responses… (More)
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Highly Cited
1994
Highly Cited
1994
Members of a family of highly conserved proteins, termed 14-3-3 proteins, were found by several experimental approaches to… (More)
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Highly Cited
1994
Highly Cited
1994
Bacterial LPS is a potent macrophage activator. The early steps in LPS signal transduction involve the tyrosine phosphorylation… (More)
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Highly Cited
1994
Highly Cited
1994
We have previously found that Raf-1, which is activated by hematopoietic growth factors in association with phosphorylation, is… (More)
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