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RAF1 gene

Known as: TRANSFORMING REPLICATION-DEFECTIVE MURINE RETROVIRUS 3611-MSV, V-RAF-1 MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1, C-Raf proto-oncogene, serine/threonine kinase 
This gene is involved in cell growth, proliferation, differentiation and migration. It also plays a role in apoptosis.
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
The Raf-1 kinase is an important signaling molecule, functioning in the Ras pathway to transmit mitogenic, differentiative, and… Expand
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Highly Cited
1999
Highly Cited
1999
Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase… Expand
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Highly Cited
1999
Highly Cited
1999
The Raf family of serine/threonine protein kinases couple growth factor receptor stimulation to mitogen activated protein kinase… Expand
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Highly Cited
1997
Highly Cited
1997
It has previously been shown that maximal activation of Raf-1 is produced by synergistic signals from oncogenic Ras and activated… Expand
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Highly Cited
1996
Highly Cited
1996
A green fluorescent protein (GFP)-Raf-1 fusion protein was used to show that Bcl-2 can target this kinase to mitochondria. Active… Expand
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Highly Cited
1996
Highly Cited
1996
c-Raf-1 (Raf-1) is a central component of signal transduction pathways stimulated by various growth factors, protein kinase C… Expand
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Highly Cited
1996
Highly Cited
1996
The Bcl-2 protein blocks programmed cell death (apoptosis) through an unknown mechanism. Previously we identified a Bcl-2… Expand
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Highly Cited
1994
Highly Cited
1994
The cytoplasmic Raf-1 kinase is essential for mitogenic signalling by growth factors, which couple to tyrosine kinases, and by… Expand
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Highly Cited
1993
Highly Cited
1993
THE Ras proteins are key regulators of the growth of eukaryotic cells, but their direct target enzymes, or 'effectors', are… Expand
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Highly Cited
1992
Highly Cited
1992
Raf-1 serine-threonine protein kinase has the hallmarks of a critical switch that connects growth factor receptor activation at… Expand
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