RAF1 gene

Known as: TRANSFORMING REPLICATION-DEFECTIVE MURINE RETROVIRUS 3611-MSV, V-RAF-1 MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1, C-Raf proto-oncogene, serine/threonine kinase 
This gene is involved in cell growth, proliferation, differentiation and migration. It also plays a role in apoptosis.
National Institutes of Health

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Cell Cycle ControlMAP Kinase Kinase Kinase 1MAP kinase kinase activityMAP3K1 gene
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RAF1 wt Allele

Papers overview

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Highly Cited
2005
Highly Cited
2005
p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association.
Raf-1 protects cells from apoptosis, independently of its signals to MEK and ERK, by translocating to the mitochondria where it… (More)
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Highly Cited
1999
Highly Cited
1999
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase… (More)
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Highly Cited
1998
Highly Cited
1998
Protein kinase G mediates vascular endothelial growth factor-induced Raf-1 activation and proliferation in human endothelial cells.
Vascular endothelial growth factor (VEGF) is an endothelium-specific, secreted protein that acts as a vasodilator, angiogenic… (More)
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Highly Cited
1998
Highly Cited
1998
Bcl-xL is phosphorylated in malignant cells following microtubule disruption.
The oncogenic protein Bcl-2 functions as a potent inhibitor of programmed cell death. This survival activity has been shown in… (More)
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Highly Cited
1997
Highly Cited
1997
Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling.
Activation of the Raf serine/threonine protein kinases is tightly regulated by multiple phosphorylation events. Phosphorylation… (More)
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Highly Cited
1996
Highly Cited
1996
Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway.
c-Raf-1 (Raf-1) is a central component of signal transduction pathways stimulated by various growth factors, protein kinase C… (More)
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1996
1996
Raf-1 kinase targets GA-binding protein in transcriptional regulation of the human immunodeficiency virus type 1 promoter.
The serine/threonine protein kinase Raf-1 is a component of a conserved intracellular signaling cascade that controls responses… (More)
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Highly Cited
1994
Highly Cited
1994
Interaction of the protein kinase Raf-1 with 14-3-3 proteins.
Members of a family of highly conserved proteins, termed 14-3-3 proteins, were found by several experimental approaches to… (More)
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Highly Cited
1994
Highly Cited
1994
Lipopolysaccharide induces activation of the Raf-1/MAP kinase pathway. A putative role for Raf-1 in the induction of the IL-1 beta and the TNF-alpha genes.
Bacterial LPS is a potent macrophage activator. The early steps in LPS signal transduction involve the tyrosine phosphorylation… (More)
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Highly Cited
1994
Highly Cited
1994
Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells.
We have previously found that Raf-1, which is activated by hematopoietic growth factors in association with phosphorylation, is… (More)
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