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RAF1 gene

Known as: TRANSFORMING REPLICATION-DEFECTIVE MURINE RETROVIRUS 3611-MSV, V-RAF-1 MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1, C-Raf proto-oncogene, serine/threonine kinase 
This gene is involved in cell growth, proliferation, differentiation and migration. It also plays a role in apoptosis.
National Institutes of Health

Related topics

Related topics

14 relations
Cell Cycle ControlMAP Kinase Kinase Kinase 1MAP kinase kinase activityMAP3K1 gene
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RAF1 wt Allele

Papers overview

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Highly Cited
2005
Highly Cited
2005
Regulation of Raf-1 by direct feedback phosphorylation.
The Raf-1 kinase is an important signaling molecule, functioning in the Ras pathway to transmit mitogenic, differentiative, and… Expand
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Highly Cited
1999
Highly Cited
1999
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase… Expand
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Highly Cited
1999
Highly Cited
1999
Serine and tyrosine phosphorylations cooperate in Raf‐1, but not B‐Raf activation
The Raf family of serine/threonine protein kinases couple growth factor receptor stimulation to mitogen activated protein kinase… Expand
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Highly Cited
1997
Highly Cited
1997
Differential Regulation of Raf-1, A-Raf, and B-Raf by Oncogenic Ras and Tyrosine Kinases*
It has previously been shown that maximal activation of Raf-1 is produced by synergistic signals from oncogenic Ras and activated… Expand
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Highly Cited
1996
Highly Cited
1996
Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria
A green fluorescent protein (GFP)-Raf-1 fusion protein was used to show that Bcl-2 can target this kinase to mitochondria. Active… Expand
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Highly Cited
1996
Highly Cited
1996
Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway.
c-Raf-1 (Raf-1) is a central component of signal transduction pathways stimulated by various growth factors, protein kinase C… Expand
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Highly Cited
1996
Highly Cited
1996
Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.
The Bcl-2 protein blocks programmed cell death (apoptosis) through an unknown mechanism. Previously we identified a Bcl-2… Expand
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Highly Cited
1994
Highly Cited
1994
Mechanism of inhibition of Raf-1 by protein kinase A.
The cytoplasmic Raf-1 kinase is essential for mitogenic signalling by growth factors, which couple to tyrosine kinases, and by… Expand
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Highly Cited
1993
Highly Cited
1993
Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro
THE Ras proteins are key regulators of the growth of eukaryotic cells, but their direct target enzymes, or 'effectors', are… Expand
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Highly Cited
1992
Highly Cited
1992
Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.
Raf-1 serine-threonine protein kinase has the hallmarks of a critical switch that connects growth factor receptor activation at… Expand
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