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RAF1 gene

Known as: TRANSFORMING REPLICATION-DEFECTIVE MURINE RETROVIRUS 3611-MSV, V-RAF-1 MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1, C-Raf proto-oncogene, serine/threonine kinase 
This gene is involved in cell growth, proliferation, differentiation and migration. It also plays a role in apoptosis.
National Institutes of Health

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Related topics

14 relations
Cell Cycle ControlMAP Kinase Kinase Kinase 1MAP kinase kinase activityMAP3K1 gene

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RAF1 wt Allele

Papers overview

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Highly Cited
2001
Highly Cited
2001
Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK–ERK independent mechanism
The Ser/Thr kinase Raf-1 is a protooncogene product that is a central component in many signaling pathways involved in normal… 
Highly Cited
1999
Highly Cited
1999
p50cdc37 Acting in Concert with Hsp90 Is Required for Raf-1 Function
ABSTRACT Genetic screens in Drosophila have identified p50 cdc37 to be an essential component of the sevenless receptor/mitogen… 
Highly Cited
1999
Highly Cited
1999
Phospholipase D and Its Product, Phosphatidic Acid, Mediate Agonist-dependent Raf-1 Translocation to the Plasma Membrane and the Activation of the Mitogen-activated Protein Kinase Pathway*
The primary known function of phospholipase D (PLD) is to generate phosphatidic acid (PA) via the hydrolysis of… 
Highly Cited
1997
Highly Cited
1997
Geldanamycin-induced destabilization of Raf-1 involves the proteasome.
The Raf-1-MEK-MAPK pathway plays an important role in transducing extracellular growth factor signaling into altered nuclear… 
Highly Cited
1996
Highly Cited
1996
Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway
The serine/threonine kinase Raf-1 functions downstream of Rats in a signal transduction cascade which transmits mitogenic stimuli… 
Highly Cited
1995
Highly Cited
1995
Two Distinct Raf Domains Mediate Interaction with Ras (*)
A key event for Ras transformation involves the direct physical association between Ras and the Raf-1 kinase. This interaction… 
Highly Cited
1994
Highly Cited
1994
Mechanism of inhibition of Raf-1 by protein kinase A
The cytoplasmic Raf-1 kinase is essential for mitogenic signalling by growth factors, which couple to tyrosine kinases, and by… 
Highly Cited
1994
Highly Cited
1994
A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function.
Ras and Raf-1 are key proteins involved in the transmission of developmental and proliferative signals generated by receptor and… 
Highly Cited
1993
Highly Cited
1993
Reconstitution of the Raf-1—MEK—ERK Signal Transduction Pathway In Vitro
Raf-1 is a serine/threonine kinase which is essential in cell growth and differentiation. Tyrosine kinase oncogenes and receptors… 
Highly Cited
1993
Highly Cited
1993
GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells.
Ras is involved in signal transduction of various factors for growth, differentiation, and oncogenesis. Recent studies have… 
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