Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 205,261,777 papers from all fields of science
Search
Sign In
Create Free Account
RAF1 gene
Known as:
TRANSFORMING REPLICATION-DEFECTIVE MURINE RETROVIRUS 3611-MSV
, V-RAF-1 MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1
, C-Raf proto-oncogene, serine/threonine kinase
Expand
This gene is involved in cell growth, proliferation, differentiation and migration. It also plays a role in apoptosis.
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
14 relations
Cell Cycle Control
MAP Kinase Kinase Kinase 1
MAP kinase kinase activity
MAP3K1 gene
Expand
Narrower (1)
RAF1 wt Allele
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Regulation of Raf-1 by direct feedback phosphorylation.
M. K. Dougherty
,
Jurgen Müller
,
+7 authors
D. Morrison
Molecular cell
2005
Corpus ID: 33026408
Highly Cited
2001
Highly Cited
2001
Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK–ERK independent mechanism
Jing Chen
,
K. Fujii
,
Lixin Zhang
,
Thomas Roberts
,
H. Fu
Proceedings of the National Academy of Sciences…
2001
Corpus ID: 37128708
The Ser/Thr kinase Raf-1 is a protooncogene product that is a central component in many signaling pathways involved in normal…
Expand
Highly Cited
1999
Highly Cited
1999
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
K. Yeung
,
T. Seitz
,
+9 authors
W. Kolch
Nature
1999
Corpus ID: 4379551
Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase…
Expand
Highly Cited
1999
Highly Cited
1999
Serine and tyrosine phosphorylations cooperate in Raf‐1, but not B‐Raf activation
C. Mason
,
C. Springer
,
R. Cooper
,
G. Superti-Furga
,
C. Marshall
,
R. Marais
The EMBO journal
1999
Corpus ID: 11170465
The Raf family of serine/threonine protein kinases couple growth factor receptor stimulation to mitogen activated protein kinase…
Expand
Highly Cited
1997
Highly Cited
1997
Differential Regulation of Raf-1, A-Raf, and B-Raf by Oncogenic Ras and Tyrosine Kinases*
R. Marais
,
Y. Light
,
H. Paterson
,
C. Mason
,
C. Marshall
The Journal of Biological Chemistry
1997
Corpus ID: 11669062
It has previously been shown that maximal activation of Raf-1 is produced by synergistic signals from oncogenic Ras and activated…
Expand
Highly Cited
1996
Highly Cited
1996
Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria
Hong-Gang Wang
,
U. Rapp
,
John Calvin Reed
Cell
1996
Corpus ID: 16559750
Highly Cited
1996
Highly Cited
1996
Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway.
M. Blagosklonny
,
T. Schulte
,
P. Nguyen
,
J. Trepel
,
L. Neckers
Cancer research
1996
Corpus ID: 1238325
c-Raf-1 (Raf-1) is a central component of signal transduction pathways stimulated by various growth factors, protein kinase C…
Expand
Review
1993
Review
1993
Protein kinase Cα activates RAF-1 by direct phosphorylation
W. Kolch
,
G. Heidecker
,
+6 authors
U. Rapp
Nature
1993
Corpus ID: 4368316
THE kinase Raf-1 can be activated by treatment of cells with mitogens and by the protein kinase C (PKC) activator 12-0…
Expand
Highly Cited
1993
Highly Cited
1993
Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro
P. Warne
,
Pablo Rodrigueza Vician
,
J. Downward
Nature
1993
Corpus ID: 4253353
THE Ras proteins are key regulators of the growth of eukaryotic cells, but their direct target enzymes, or 'effectors', are…
Expand
Highly Cited
1992
Highly Cited
1992
Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.
J. Bruder
,
G. Heidecker
,
U. Rapp
Genes & development
1992
Corpus ID: 28501757
Raf-1 serine-threonine protein kinase has the hallmarks of a critical switch that connects growth factor receptor activation at…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
,
Terms of Service
, and
Dataset License
ACCEPT & CONTINUE