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RAF1 gene

Known as: TRANSFORMING REPLICATION-DEFECTIVE MURINE RETROVIRUS 3611-MSV, V-RAF-1 MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1, C-Raf proto-oncogene, serine/threonine kinase 
This gene is involved in cell growth, proliferation, differentiation and migration. It also plays a role in apoptosis.
National Institutes of Health

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Related topics

14 relations
Cell Cycle ControlMAP Kinase Kinase Kinase 1MAP kinase kinase activityMAP3K1 gene

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RAF1 wt Allele

Papers overview

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Highly Cited
2005
Highly Cited
2005
Regulation of Raf-1 by direct feedback phosphorylation.
Highly Cited
2001
Highly Cited
2001
Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK–ERK independent mechanism
The Ser/Thr kinase Raf-1 is a protooncogene product that is a central component in many signaling pathways involved in normal… 
Highly Cited
1999
Highly Cited
1999
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase… 
Highly Cited
1999
Highly Cited
1999
Serine and tyrosine phosphorylations cooperate in Raf‐1, but not B‐Raf activation
The Raf family of serine/threonine protein kinases couple growth factor receptor stimulation to mitogen activated protein kinase… 
Highly Cited
1997
Highly Cited
1997
Differential Regulation of Raf-1, A-Raf, and B-Raf by Oncogenic Ras and Tyrosine Kinases*
It has previously been shown that maximal activation of Raf-1 is produced by synergistic signals from oncogenic Ras and activated… 
Highly Cited
1996
Highly Cited
1996
Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria
Highly Cited
1996
Highly Cited
1996
Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway.
c-Raf-1 (Raf-1) is a central component of signal transduction pathways stimulated by various growth factors, protein kinase C… 
Review
1993
Review
1993
Protein kinase Cα activates RAF-1 by direct phosphorylation
THE kinase Raf-1 can be activated by treatment of cells with mitogens and by the protein kinase C (PKC) activator 12-0… 
Highly Cited
1993
Highly Cited
1993
Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro
THE Ras proteins are key regulators of the growth of eukaryotic cells, but their direct target enzymes, or 'effectors', are… 
Highly Cited
1992
Highly Cited
1992
Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.
Raf-1 serine-threonine protein kinase has the hallmarks of a critical switch that connects growth factor receptor activation at… 
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