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Interleukin-2: inception, impact, and implications.
  • K. Smith
  • Biology, Medicine
  • 27 May 1988
Because T cell clonal proliferation after antigen challenge is obligatory for immune responsiveness and immune memory, the IL-2-T cell system has opened the way to a molecular understanding of phenomena that are fundamental to biology, immunology, and medicine.
T cell growth factor: parameters of production and a quantitative microassay for activity.
This highly reproducible, quantitative assay for T cell growth factor (TCGF), based upon the tritiated-thymidine incorporation of continuous murine tumor-specific cytotoxic T cell lines (CTLL), has revealed that T lymphocytes are required for its production.
The interleukin-2 T-cell system: a new cell growth model.
Since the proliferative characteristics of T cells are identical to those of both prokaryotic and all other eukaryotic cells, these findings provide a new model that accounts fully for the variables that determine cell cycle progression.
Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors
The constitutive expression of this functional high affinity IL-2 receptor on a small population of resting NK cells provides further evidence in support of a role for these cells in the host's early defense against viral infection or malignant transformation, before the more delayed but specific T cell response.
PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding.
A novel mechanism by which function of a lineage-specific transcription factor is inhibited by another lineage-restricted factor through direct protein-protein interactions is demonstrated, contributing to understanding how protein- protein interactions participate in hematopoietic differentiation and leukemogenesis.
Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation
Thalidomide inhibition of lipopolysaccharide-induced tumor necrosis factor alpha production is examined and it is found that the drug enhances the degradation of TNF-alpha mRNA, providing an explanation for the synergistic effects of these drugs.
c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function.
It is shown that the mice with a null mutation in the lymphoid-specific c-Rel gene have normal development of lymphoid tissues and T cell compartment, however, T cells derived from the c- Rel knockout mice have several functional abnormalities, suggesting that c-rel is important for inducible cytokine and cytokine receptor expression, and a key regulator of early activation and proliferation in T cells.
Distribution of the Na,K-ATPase α Subunit in the Rat Spiral Ganglion and Organ of Corti
Findings suggest that both the NKA α1 and NKAα3 are poised to play an essential role in the regulation of the type I afferent synapses, the medial efferentsynapses, and also glutamate transport from the afferent-inner hair cell synapse.
Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors.
A lentiviral vector was able to transduce human CD34+ cells capable of stable, long-term reconstitution of nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice and resulted in transgene expression in multiple lineages of human hematopoietic cells for up to 22 weeks after transplantation.
Isolation of interleukin 2-induced immediate-early genes.
The results indicate that the effects of IL-2 are mediated by the specific induction of a number of immediate-early genes and provide a means with which to further delineate the mechanisms wherebyIL-2 stimulates T-lymphocyte proliferation and differentiation.