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RAF1 wt Allele

Known as: cRAF, v-RAF-1 Murine Leukemia Viral Oncogene Homolog 1wt Allele, Raf-1 
Human RAF1 wild-type allele is located within 3p25 and is approximately 81 kb in length. This allele, which encodes RAF proto-oncogene serine… 
National Institutes of Health

Related topics

Related topics

34 relations
3p25Angiotensin II Signaling PathwayB Cell Receptor Signaling PathwayCCR3 Signaling Pathway

Broader (1)

RAF1 gene

Papers overview

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Highly Cited
2005
Highly Cited
2005
p21-activated Kinase 1 (Pak1)-dependent Phosphorylation of Raf-1 Regulates Its Mitochondrial Localization, Phosphorylation of BAD, and Bcl-2 Association*
Raf-1 protects cells from apoptosis, independently of its signals to MEK and ERK, by translocating to the mitochondria where it… 
Highly Cited
1998
Highly Cited
1998
2-Methoxyestradiol-induced phosphorylation of Bcl-2: uncoupling from JNK/SAPK activation.
The natural estrogen metabolite 2-methoxyestradiol (2ME) is anti-angiogenic in vivo and a strong growth inhibitor in vitro. The… 
Highly Cited
1996
Highly Cited
1996
Cross-talk between Different Enhancer Elements during Mitogenic Induction of the Human Stromelysin-1 Gene*
Platelet-derived growth factor (PDGF) induces the expression of human stromelysin-1, a matrix metalloproteinase involved in tumor… 
Highly Cited
1994
Highly Cited
1994
Cross-linking of surface IgM stimulates the Ras/Raf-1/MEK/MAPK cascade in human B lymphocytes.
Highly Cited
1993
Highly Cited
1993
GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells.
Ras is involved in signal transduction of various factors for growth, differentiation, and oncogenesis. Recent studies have… 
Highly Cited
1992
Highly Cited
1992
Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase.
The raf genes encode a family of cytoplasmic proteins with intrinsic protein-serine/threonine kinase activity. The c-raf gene is… 
Highly Cited
1991
Highly Cited
1991
Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo.
MAP (mitogen-activated protein) kinase is shown to phosphorylate baculovirally expressed Raf-1 in vitro, generating one major… 
Highly Cited
1991
Highly Cited
1991
Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor-dependent myeloid cell line.
The product of the c-raf-1 proto-oncogene, Raf-1, is a 74,000-dalton cytoplasmic serine/threonine protein kinase that has been… 
Highly Cited
1990
Highly Cited
1990
Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation.
Highly Cited
1989
Highly Cited
1989
Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor
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