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RABEP1 protein, human

Known as: neurocrescin protein, human, RAB5EP protein, human, neurocrescin, NOGF protein, human 
Rab GTPase-binding effector protein 1 (862 aa, ~99 kDa) is encoded by the human RABEP1 gene. This protein is involved in both the mediation of… Expand
National Institutes of Health

Related topics

Related topics

8 relations
CytoplasmEarly endosomeEndocytosisRABEP1 gene
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Broader (1)

Vesicular Transport Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
VipD of Legionella pneumophila Targets Activated Rab5 and Rab22 to Interfere with Endosomal Trafficking in Macrophages
Upon phagocytosis, Legionella pneumophila translocates numerous effector proteins into host cells to perturb cellular metabolism… Expand
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2012
2012
Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin
Tuberous sclerosis complex (TSC) is a genetic disorder characterized by the development of hamartomas in multiple organs… Expand
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Highly Cited
2006
Highly Cited
2006
The Rab5 Guanine Nucleotide Exchange Factor Rabex-5 Binds Ubiquitin (Ub) and Functions as a Ub Ligase through an Atypical Ub-interacting Motif and a Zinc Finger Domain*
Rabex-5, the mammalian orthologue of yeast Vps9p, is a guanine nucleotide exchange factor for Rab5. Rabex-5 forms a tight complex… Expand
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2003
2003
Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomes.
Rab4 regulates recycling from early endosomes. We investigated the role of the rab4 effector rabaptin-5alpha and its putative… Expand
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2002
2002
Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain.
In yeast two-hybrid screening using gamma1-adaptin, a subunit of the AP-1 adaptor complex of clathrin-coated vesicles derived… Expand
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Highly Cited
2001
Highly Cited
2001
Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER.
The role of rab33b, a Golgi-specific rab protein, was investigated. Microinjection of rab33b mutants stabilised in the GTP… Expand
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Highly Cited
2000
Highly Cited
2000
Selective Membrane Recruitment of EEA1 Suggests a Role in Directional Transport of Clathrin-coated Vesicles to Early Endosomes*
The molecular mechanisms ensuring directionality of endocytic membrane trafficking between transport vesicles and target… Expand
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Highly Cited
1997
Highly Cited
1997
The Tuberous Sclerosis 2 Gene Product, Tuberin, Functions as a Rab5 GTPase Activating Protein (GAP) in Modulating Endocytosis*
The tuberous sclerosis complex 2 (TSC2) is a tumor suppressor gene that plays a causative role in the autosomal dominant syndrome… Expand
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Highly Cited
1997
Highly Cited
1997
A Novel Rab5 GDP/GTP Exchange Factor Complexed to Rabaptin-5 Links Nucleotide Exchange to Effector Recruitment and Function
The small GTPase Rab5 plays an essential role in endocytic traffic. Rab GDP dissociation inhibitor delivers Rab5 to the membrane… Expand
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Highly Cited
1995
Highly Cited
1995
Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion
We have identified a novel 100 kDa coiled-coil protein, rabaptin-5, that specifically interacts with the GTP form of the small… Expand
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