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- Publications
- Influence
Imaging Intracellular Fluorescent Proteins at Nanometer Resolution
- E. Betzig, G. Patterson, +6 authors H. Hess
- Biology, Medicine
- Science
- 15 September 2006
We introduce a method for optically imaging intracellular proteins at nanometer spatial resolution. Numerous sparse subsets of photoactivatable fluorescent protein molecules were activated, localized… Expand
Signals for sorting of transmembrane proteins to endosomes and lysosomes.
- J. Bonifacino, L. Traub
- Biology, Medicine
- Annual review of biochemistry
- 28 November 2003
Sorting of transmembrane proteins to endosomes and lysosomes is mediated by signals present within the cytosolic domains of the proteins. Most signals consist of short, linear sequences of amino acid… Expand
Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor
- Cecilia N Arighi, L. Hartnell, R. C. Aguilar, C. Haft, J. Bonifacino
- Biology, Medicine
- The Journal of cell biology
- 12 April 2004
The cation-independent mannose 6-phosphate receptor (CI-MPR) mediates sorting of lysosomal hydrolase precursors from the TGN to endosomes. After releasing the hydrolase precursors into the endosomal… Expand
The Mechanisms of Vesicle Budding and Fusion
- J. Bonifacino, B. Glick
- Biology, Medicine
- Cell
- 23 January 2004
Genetic and biochemical analyses of the secretory pathway have produced a detailed picture of the molecular mechanisms involved in selective cargo transport between organelles. This transport occurs… Expand
Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER
- J. Lippincott-Schwartz, L. Yuan, J. Bonifacino, R. Klausner
- Biology, Medicine
- Cell
- 10 March 1989
Abstract
In cells treated with brefeldin A (BFA), movement of newly synthesized membrane proteins from the endoplasmic reticulum (ER) to the Golgi apparatus was blocked. Surprisingly, the… Expand
Retrograde transport from endosomes to the trans-Golgi network
- J. Bonifacino, R. Rojas
- Biology, Medicine
- Nature Reviews Molecular Cell Biology
- 1 August 2006
A subset of intracellular transmembrane proteins such as acid-hydrolase receptors, processing peptidases and SNAREs, as well as extracellular protein toxins such as Shiga toxin and ricin, undergoes… Expand
Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7
- R. Rojas, Thijs van Vlijmen, +7 authors J. Bonifacino
- Biology, Medicine
- The Journal of cell biology
- 3 November 2008
The retromer complex mediates retrograde transport of transmembrane cargo from endosomes to the trans-Golgi network (TGN). Mammalian retromer is composed of a sorting nexin (SNX) dimer that binds to… Expand
GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex.
- E. C. Dell'angelica, R. Puertollano, +4 authors J. Bonifacino
- Biology, Medicine
- The Journal of cell biology
- 3 April 2000
Formation of intracellular transport intermediates and selection of cargo molecules are mediated by protein coats associated with the cytosolic face of membranes. Here, we describe a novel family of… Expand
Interaction of tyrosine-based sorting signals with clathrin-associated proteins.
- H. Ohno, J. Stewart, +7 authors J. Bonifacino
- Biology, Medicine
- Science
- 29 September 1995
Tyrosine-based signals within the cytoplasmic domain of integral membrane proteins mediate clathrin-dependent protein sorting in the endocytic and secretory pathways. A yeast two-hybrid system was… Expand
Sorting of lysosomal proteins.
- T. Braulke, J. Bonifacino
- Biology, Medicine
- Biochimica et biophysica acta
- 1 April 2009
Lysosomes are composed of soluble and transmembrane proteins that are targeted to lysosomes in a signal-dependent manner. The majority of soluble acid hydrolases are modified with mannose 6-phosphate… Expand