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Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.
Lateral inhibition, mediated by Notch signaling, leads to the selection of cells that are permitted to become neurons within domains defined by proneural gene expression. Reduced lateral inhibitionExpand
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Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli.
To determine why proteasome inhibitors prevent thymocyte death, we examined whether proteasomes degrade anti-apoptotic molecules in cells induced to undergo apoptosis. The c-IAP1 and XIAP inhibitorsExpand
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RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.
A RING finger-containing protein (AO7) that binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination was identified. Mutations of cation-coordinating residuesExpand
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SINAT5 promotes ubiquitin-related degradation of NAC1 to attenuate auxin signals
The plant hormone indole-3 acetic acid (IAA or auxin) controls many aspects of plant development, including the production of lateral roots. Ubiquitin-mediated proteolysis has a central role in thisExpand
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Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53*
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation. We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its activity isExpand
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RING Finger Proteins Mediators of Ubiquitin Ligase Activity
Ubiquitination is a highly regulated and common cellular process with E3s as central players. RING finger proteins represent the largest class of E3s to date. Whether RING fingers are primarilyExpand
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The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum
gp78, also known as the tumor autocrine motility factor receptor, is a transmembrane protein whose expression is correlated with tumor metastasis. We establish that gp78 is a RING finger-dependentExpand
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HECT and RING finger families of E3 ubiquitin ligases at a glance
The post-translational attachment of ubiquitin, a highly conserved 76-amino-acid polypeptide, directs myriad eukaryotic proteins to a variety of fates and functions. Ubiquitylation is best-known forExpand
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Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.
The conjugation of proteins with ubiquitin plays numerous regulatory roles through both proteasomal-dependent and nonproteasomal-dependent functions. Alterations in ubiquitylation are observed in aExpand
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The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site.
Efficient targeting of proteins for degradation from the secretory pathway is essential to homeostasis. This occurs through endoplasmic reticulum (ER)-associated degradation (ERAD). In this study, weExpand
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