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Rab GTPases as coordinators of vesicle traffic
- H. Stenmark
- BiologyNature Reviews Molecular Cell Biology
- 1 August 2009
Crosstalk between multiple Rab GTPases through shared effectors, or through effectors that recruit selective Rab activators, ensures the spatiotemporal regulation of vesicle traffic.
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
Autophagic degradation of ubiquitinated protein aggregates is important for cell survival, but it is not known how the autophagic machinery recognizes such aggregates. In this study, we report that…
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
The endosomal sorting complex required for transport (ESCRT) machinery sorts cargo labelled with ubiquitin into invaginations of endosome membranes and mediates the breaking off of the cargo-containing intraluminal vesicles from the perimeter membrane.
Localization of phosphatidylinositol 3‐phosphate in yeast and mammalian cells
- D. Gillooly, Isabel C. Morrow, H. Stenmark
- Biology, Computer ScienceThe EMBO journal
- 1 September 2000
PI(3)P follows a conserved intralumenal degradation pathway, and its generation, accessibility and turnover are likely to play a crucial role in defining the early endosomes and the subsequent steps leading to multivesicular endosome formation.
EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
The identification of EEA1 as a direct Rab5 effector provides a molecular link between PI(3)K and Rab5, and its restricted distribution to early endosomes indicates that EEA 1 may confer directionality to Rab5-dependent endocytic transport.
Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes
- K. Bache, A. Brech, A. Mehlum, H. Stenmark
- Biology, Computer ScienceThe Journal of cell biology
- 4 August 2003
It is concluded that Hrs mediates the initial recruitment of ESCRT-I to endosomes and, thereby, indirectly regulates multivesicular body formation.
EEA1, an Early Endosome-Associated Protein.
It is proposed that EEA1 is required for vesicular transport of proteins through early endosomes and that its finger motifs are required for this activity.
Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.