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- Publications
- Influence
Rab GTPases as coordinators of vesicle traffic
- H. Stenmark
- Biology, Medicine
- Nature Reviews Molecular Cell Biology
- 1 August 2009
Membrane trafficking between organelles by vesiculotubular carriers is fundamental to the existence of eukaryotic cells. Central in ensuring that cargoes are delivered to their correct destinations… Expand
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
- G. Bjørkøy, T. Lamark, +5 authors T. Johansen
- Biology, Medicine
- The Journal of cell biology
- 21 November 2005
Autophagic degradation of ubiquitinated protein aggregates is important for cell survival, but it is not known how the autophagic machinery recognizes such aggregates. In this study, we report that… Expand
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
- D. Klionsky, H. Abeliovich, +233 authors R. Deter
- Biology, Medicine
- Autophagy
- 16 February 2008
Research in autophagy continues to accelerate,(1) and as a result many new scientists are entering the field. Accordingly, it is important to establish a standard set of criteria for monitoring… Expand
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
- C. Raiborg, H. Stenmark
- Biology, Medicine
- Nature
- 26 March 2009
Selective trafficking of membrane proteins to lysosomes for destruction is required for proper cell signalling and metabolism. Ubiquitylation aids this process by specifying which proteins should be… Expand
Localization of phosphatidylinositol 3‐phosphate in yeast and mammalian cells
- D. Gillooly, I. Morrow, +5 authors H. Stenmark
- Biology, Medicine
- The EMBO journal
- 1 September 2000
Phosphatidylinositol 3‐kinase (PI3K) regulates several vital cellular processes, including signal transduction and membrane trafficking. In order to study the intracellular localization of the PI3K… Expand
EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
- A. Simonsen, R. Lippé, +7 authors H. Stenmark
- Biology, Medicine
- Nature
- 30 July 1998
GTPases and lipid kinases regulate membrane traffic along the endocytic pathway by mechanisms that are not completely understood. Fusion between early endosomes requires phosphatidyl-inositol-3-OH… Expand
Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis.
- H. Stenmark, R. Parton, O. Steele-Mortimer, A. Lütcke, J. Gruenberg, M. Zerial
- Biology, Medicine
- The EMBO journal
- 1 March 1994
Small GTPases of the rab family control distinct steps of intracellular transport. The function of their GTPase activity is not completely understood. To investigate the role of the nucleotide state… Expand
Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes
- Kristi G Bache, A. Brech, A. Mehlum, H. Stenmark
- Biology, Medicine
- The Journal of cell biology
- 4 August 2003
Hrs and the endosomal sorting complexes required for transport, ESCRT-I, -II, and -III, are involved in the endosomal sorting of membrane proteins into multivesicular bodies and lysosomes or… Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- D. Klionsky, Kotb Abdelmohsen, +2,464 authors S. Zughaier
- Biology, Medicine
- Autophagy
- 18 April 2012
In 2008 we published the first set of guidelines for
standardizing research in autophagy. Since then, research on
this topic has continued to accelerate, and many new scientists
have entered the… Expand
EEA1, an Early Endosome-Associated Protein.
- F. Mu, J. Callaghan, +7 authors B. H. Toh
- Biology, Medicine
- The Journal of Biological Chemistry
- 2 June 1995
Early endosomes are cellular compartments receiving endocytosed material and sorting them for vesicular transport to late endosomes and lysosomes or for recycling to the plasma membrane. We have… Expand