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Rab11 regulates recycling through the pericentriolar recycling endosome
A novel role for rab11 in controlling traffic through the recycling endosome is suggested after functional studies showed that the early steps of uptake and recycling for transferrin were not affected by overexpression of rab11 proteins. Expand
Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide.
In conclusion, immunological factors may play a hitherto underestimated role in suicide, and microglial activation might be interpreted as a consequence of presuicidal stress. Expand
Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion
Rabies5 recruits rabaptin-5 to purified early endosomes in a GTP-dependent manner, demonstrating functional similarities with other members of the Ras superfamily. Expand
The Endocannabinoid Anandamide Protects Neurons during CNS Inflammation by Induction of MKP-1 in Microglial Cells
The release of AEA in injured CNS tissue might represent a new mechanism of neuro-immune communication during CNS injury, which controls and limits immune response after primary CNS damage. Expand
Proteasome inhibition by paired helical filament‐tau in brains of patients with Alzheimer's disease
It is suggested that PHF‐tau is able directly to induce neuronal damage in the AD brain, as the proteasome activity in human brains strongly correlated with the amount of co‐precipitated PHF-tau during immunoprecipitation of proteasomes. Expand
Biochemical analysis of distinct Rab5- and Rab11-positive endosomes along the transferrin pathway.
The protein composition of Rab5- and Rab11-carrying endosomes is analysed to gain further insight into the compartmental organization of the endocytic and recycling pathway, and data suggest an organizations of the transferrin pathway into distinct Rab 5- andrab11-positive compartments. Expand
Microglia provide neuroprotection after ischemia
Many neurological insults are accompanied by a marked acute inflammatory reaction, involving the activation of microglia. Using a model of exogenous application of fluorescence‐labeled BV2 microgliaExpand
Comparative resistance of the 20S and 26S proteasome to oxidative stress.
The 20S proteasome was more resistant to oxidative stress than the ATP- and ubiquitin-dependent 26S proteasant system, and Lysates from K562 cells are able to degrade oxidized ferritin at a higher rate than non-oxidized ferrisin, in an ATP-independent manner. Expand
Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins.
Rab3A GDP dissociation inhibitor (GDI) removed from the membrane all rab proteins tested and inhibited the membrane binding of in vitro translated rab proteins, however, rab3A GDI had a limited effect on the membrane association of a mutant rab5 protein which contained a farnesylated cysteine motif. Expand
Membrane association of Rab5 mediated by GDP-dissociation inhibitor and accompanied by GDP/GTP exchange
The results indicate that there is a multistep mechanism for the insertion of Rab5 into the membrane which is mediated by a guanine-nucleotide-exchange factor. Expand