Quinacrine

Known as: N(4)-(6-chloro-2-Methoxy-9-acridinyl)-N(1),N(1)-diethyl-1,4-pentanediamine, 6-chloro-9-((4-(Diethylamino)-1-methylbutyl)amino)-2-methoxyacridine, 3-chloro-7-Methoxy-9-(1-methyl-4-diethylaminobutylamino)acridine 
An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
BACKGROUND The propagation of prions, the causative agents of Creutzfeldt-Jakob disease and other human prion diseases, requires… (More)
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Highly Cited
2003
Highly Cited
2003
Based on in vitro observations in scrapie-infected neuroblastoma cells, quinacrine has recently been proposed as a treatment for… (More)
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Highly Cited
1998
Highly Cited
1998
Phosphorothioate oligodeoxynucleotides containing CpG (CpG-ODN) activate immune responses. We report that quinacrine, chloroquine… (More)
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Highly Cited
1997
Highly Cited
1997
Human spermatozoa possess a specialized capacity to generate reactive oxygen species (ROS) that is thought to be of significance… (More)
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Highly Cited
1994
Highly Cited
1994
The signaling pathways involved in the long-term metabolic effects of angiotensin II (Ang II) in vascular smooth muscle cells are… (More)
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Highly Cited
1993
Highly Cited
1993
Two likely mechanisms for the initiation of arterial platelet thrombus formation under conditions of elevated fluid shear… (More)
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Highly Cited
1992
Highly Cited
1992
Chromosomes of Poecilia mexicana mexicana, one of the bisexual species involved in the hybrid origin of the unisexual teleost… (More)
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Highly Cited
1986
Highly Cited
1986
In cascade perfusion and superfusion experiments on rabbit tissues, when acetylcholine (ACh) was introduced into the circuit so… (More)
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Highly Cited
1979
Highly Cited
1979
The establishment, characterization, and tumorigenicity of a new epithelial cell line (PC-3) from a human prostatic… (More)
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Highly Cited
1973
Highly Cited
1973
CELLS from nine consecutive patients with chronic myelogenous leukaemia (CML) have been analysed with quinacrine fluorescence and… (More)
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