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Ca2+ signaling mediated by phospholipase C that produces inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] and diacylglycerol (DAG… Expand Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder maintained by cancer stem cells. To target this population… Expand Metabolic syndrome is common in the general population, but there is little information available on the underlying signaling… Expand Waldenström macroglobulinemia (WM) is an incurable lymphoplasmacytic lymphoma with limited options of therapy. Protein kinase… Expand Activation of protein kinase Cbeta (PKCbeta) has been repeatedly implicated in tumor-induced angiogenesis. The PKCbeta-selective… Expand Nickel(II), palladium(II), and platinum(II) complexes of meso-aryl-substituted hexaphyrin have been prepared and structurally… Expand Summary: Splenic peripheral B‐cell development and the events regulating this functionally significant but relatively poorly… Expand A novel murine membrane-associated protein kinase, PKK (protein kinase C-associatedkinase), was cloned on the basis of its… Expand The protein kinase Cbeta (PKCbeta) gene encodes two isoforms, PKCbetaI and PKCbetaII, as a result of alternative splicing. The… Expand Previous studies have suggested that protein kinase C (PKC) may play an important role in colon carcinogenesis and that human… Expand