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Protein Kinase C beta

Known as: protein kinase c(beta), beta pkc, pkc beta 
PKC beta encodes two proteins (PKCB1 and PKCBII) generated by alternative splicing of C-terminal exons. It is widely distributed with wide-ranging… Expand
National Institutes of Health

Related topics

Related topics

13 relations
In BloodPRKCB geneProcess of secretionantagonists & inhibitors
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Narrower (3)

PRKCB protein, humanProtein Kinase C beta1Protein Kinase C beta2

Broader (2)

PRKCB wt AlleleProtein Kinase C

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cbeta.
Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder maintained by cancer stem cells. To target this population… Expand
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2008
2008
Protein kinase C deficiency increases fatty acid oxidation and reduces fat storage.
Metabolic syndrome is common in the general population, but there is little information available on the underlying signaling… Expand
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2008
2008
Inhibition of protein kinase Cbeta prevents foam cell formation by reducing scavenger receptor A expression in human macrophages.
BACKGROUND Low-density lipoprotein (LDL) uptake by monocyte-derived macrophages is a crucial step in foam cell formation and… Expand
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Highly Cited
2007
Highly Cited
2007
Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia.
Waldenström macroglobulinemia (WM) is an incurable lymphoplasmacytic lymphoma with limited options of therapy. Protein kinase… Expand
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2007
2007
Inhibition of protein kinase Cbeta by enzastaurin enhances radiation cytotoxicity in pancreatic cancer.
PURPOSE Aberrant activation of protein kinase Cbeta (PKCbeta) by pancreatic cancer cells facilitates angiogenesis and tumor cell… Expand
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Highly Cited
2005
Highly Cited
2005
The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma…
Activation of protein kinase Cbeta (PKCbeta) has been repeatedly implicated in tumor-induced angiogenesis. The PKCbeta-selective… Expand
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2005
2005
Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation.
Protein kinase C (PKC)-induced phosphorylation of cardiac troponin I (cTnI) depresses the acto-myosin interaction and may be… Expand
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2003
2003
A catalytically inactive form of protein kinase C-associated kinase/receptor interacting protein 4, a protein kinase C beta-associated kinase that mediates NF-kappa B activation, interferes with…
Protein kinase C-associated kinase (PKK)/receptor interacting protein 4 (RIP4) is a protein kinase C (PKC) beta-associated kinase… Expand
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2001
2001
Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase.
A novel murine membrane-associated protein kinase, PKK (protein kinase C-associated kinase), was cloned on the basis of its… Expand
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2000
2000
Peptide phosphorylation by calcium-dependent protein kinase from maize seedlings.
Ca2+-dependent protein kinase (CDPK-1) was purified from maize seedlings, and its substrate specificity studied using a set of… Expand
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