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Protein Kinase C beta

Known as: protein kinase c(beta), beta pkc, pkc beta 
PKC beta encodes two proteins (PKCB1 and PKCBII) generated by alternative splicing of C-terminal exons. It is widely distributed with wide-ranging… Expand
National Institutes of Health

Related topics

Related topics

13 relations
In BloodPRKCB geneProcess of secretionantagonists & inhibitors
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Narrower (3)

PRKCB protein, humanProtein Kinase C beta1Protein Kinase C beta2

Broader (2)

PRKCB wt AlleleProtein Kinase C

Papers overview

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Highly Cited
2010
Highly Cited
2010
Ca2+ influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B cells
Ca2+ signaling mediated by phospholipase C that produces inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] and diacylglycerol (DAG… Expand
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2009
2009
BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cbeta.
Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder maintained by cancer stem cells. To target this population… Expand
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Highly Cited
2008
Highly Cited
2008
Protein Kinase Cβ Deficiency Increases Fatty Acid Oxidation and Reduces Fat Storage*
Metabolic syndrome is common in the general population, but there is little information available on the underlying signaling… Expand
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Highly Cited
2007
Highly Cited
2007
Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia.
Waldenström macroglobulinemia (WM) is an incurable lymphoplasmacytic lymphoma with limited options of therapy. Protein kinase… Expand
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Highly Cited
2005
Highly Cited
2005
The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma…
Activation of protein kinase Cbeta (PKCbeta) has been repeatedly implicated in tumor-induced angiogenesis. The PKCbeta-selective… Expand
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Highly Cited
2005
Highly Cited
2005
Group 10 metal complexes of meso-aryl-substituted [26]hexaphyrins with a metal-carbon bond.
Nickel(II), palladium(II), and platinum(II) complexes of meso-aryl-substituted [26]hexaphyrin have been prepared and structurally… Expand
Review
2004
Review
2004
Signaling in transitional type 2 B cells is critical for peripheral B‐cell development
Summary:  Splenic peripheral B‐cell development and the events regulating this functionally significant but relatively poorly… Expand
Highly Cited
2001
Highly Cited
2001
Protein Kinase C-associated Kinase (PKK), a Novel Membrane-associated, Ankyrin Repeat-containing Protein Kinase*
A novel murine membrane-associated protein kinase, PKK (protein kinase C-associatedkinase), was cloned on the basis of its… Expand
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1998
1998
Insulin regulates protein kinase CbetaII expression through enhanced exon inclusion in L6 skeletal muscle cells. A novel mechanism of insulin- and insulin-like growth factor-i-induced 5' splice site…
The protein kinase Cbeta (PKCbeta) gene encodes two isoforms, PKCbetaI and PKCbetaII, as a result of alternative splicing. The… Expand
1994
1994
Expression of multiple isoforms of protein kinase C in normal human colon mucosa and colon tumors and decreased levels of protein kinase C β and η mRNAs in the tumors
Previous studies have suggested that protein kinase C (PKC) may play an important role in colon carcinogenesis and that human… Expand
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