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Protein Kinase C beta
Known as:
protein kinase c(beta)
, beta pkc
, pkc beta
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PKC beta encodes two proteins (PKCB1 and PKCBII) generated by alternative splicing of C-terminal exons. It is widely distributed with wide-ranging…
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National Institutes of Health
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Related topics
Related topics
13 relations
In Blood
PRKCB gene
Process of secretion
antagonists & inhibitors
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Narrower (3)
PRKCB protein, human
Protein Kinase C beta1
Protein Kinase C beta2
Broader (2)
PRKCB wt Allele
Protein Kinase C
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Ca2+ influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B cells
T. Numaga
,
M. Nishida
,
+8 authors
Y. Mori
Journal of Cell Science
2010
Corpus ID: 25508169
Ca2+ signaling mediated by phospholipase C that produces inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] and diacylglycerol (DAG…
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Highly Cited
2009
Highly Cited
2009
BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cbeta.
F. Pellicanò
,
M. Copland
,
H. Jørgensen
,
J. Mountford
,
B. Leber
,
T. Holyoake
Blood
2009
Corpus ID: 23798676
Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder maintained by cancer stem cells. To target this population…
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2008
2008
Inhibition of Protein Kinase C&bgr; Prevents Foam Cell Formation by Reducing Scavenger Receptor A Expression in Human Macrophages
E. Osto
,
A. Kouroedov
,
+8 authors
F. Cosentino
Circulation
2008
Corpus ID: 58619
Background— Low-density lipoprotein (LDL) uptake by monocyte-derived macrophages is a crucial step in foam cell formation and…
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Highly Cited
2007
Highly Cited
2007
Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia.
A. Moreau
,
X. Jia
,
+15 authors
I. Ghobrial
Blood
2007
Corpus ID: 23714161
Waldenström macroglobulinemia (WM) is an incurable lymphoplasmacytic lymphoma with limited options of therapy. Protein kinase…
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Highly Cited
2005
Highly Cited
2005
The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma…
J. Graff
,
A. McNulty
,
+16 authors
D. Thornton
Cancer research
2005
Corpus ID: 5828049
Activation of protein kinase Cbeta (PKCbeta) has been repeatedly implicated in tumor-induced angiogenesis. The PKCbeta-selective…
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Highly Cited
2005
Highly Cited
2005
Group 10 metal complexes of meso-aryl-substituted [26]hexaphyrins with a metal-carbon bond.
Shigeki Mori
,
Soji Shimizu
,
R. Taniguchi
,
A. Osuka
Inorganic chemistry
2005
Corpus ID: 42772518
Nickel(II), palladium(II), and platinum(II) complexes of meso-aryl-substituted [26]hexaphyrin have been prepared and structurally…
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Review
2004
Review
2004
Signaling in transitional type 2 B cells is critical for peripheral B‐cell development
Thomas T. Su
,
B. Guo
,
B. Wei
,
J. Braun
,
D. Rawlings
Immunological reviews
2004
Corpus ID: 6290707
Summary: Splenic peripheral B‐cell development and the events regulating this functionally significant but relatively poorly…
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2002
2002
Obligatory Role of Protein Kinase C&bgr; and MARCKS in Vesicular Trafficking in Living Neurons
Hong Yang
,
Xiangyu Wang
,
C. Sumners
,
M. Raizada
Hypertension
2002
Corpus ID: 6068366
Neurotransmitter release from neurons involves both vesicular trafficking and subsequent fusion of synaptic vesicles with the…
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Highly Cited
2001
Highly Cited
2001
Protein Kinase C-associated Kinase (PKK), a Novel Membrane-associated, Ankyrin Repeat-containing Protein Kinase*
L. Chen
,
K. Haider
,
M. Ponda
,
A. Cariappa
,
D. Rowitch
,
S. Pillai
The Journal of Biological Chemistry
2001
Corpus ID: 23935150
A novel murine membrane-associated protein kinase, PKK (protein kinase C-associatedkinase), was cloned on the basis of its…
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1998
1998
Insulin regulates protein kinase CbetaII expression through enhanced exon inclusion in L6 skeletal muscle cells. A novel mechanism of insulin- and insulin-like growth factor-i-induced 5' splice site…
C. Chalfant
,
J. Watson
,
+5 authors
D. Cooper
The Journal of biological chemistry
1998
Corpus ID: 40619807
The protein kinase Cbeta (PKCbeta) gene encodes two isoforms, PKCbetaI and PKCbetaII, as a result of alternative splicing. The…
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