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Hepatic toxicity resulting from cancer treatment.
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CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy
TLDR
Investigation of human transcriptomes before and during nivolumab therapy revealed that clinical benefits correlate with reduced expression of SLC3A2 and increased IFNγ and CD8 and targeting this pathway in combination with checkpoint blockade is a potential therapeutic approach.
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Analysis of radiation-induced liver disease using the Lyman NTCP model.
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MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells
TLDR
The results demonstrate that miR-34 may restore, at least in part, the tumor suppressing function of the p53 in p53-deficient human pancreatic cancer cells.
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Functional diffusion map: a noninvasive MRI biomarker for early stratification of clinical brain tumor response.
TLDR
Overall, fDM analysis provided an early biomarker for predicting treatment response in brain tumor patients, revealing that early changes in tumor diffusion values could be used as a prognostic indicator of subsequent volumetric tumor response.
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Outcomes After Stereotactic Body Radiotherapy or Radiofrequency Ablation for Hepatocellular Carcinoma.
TLDR
Although these data are retrospective, SBRT appears to be a reasonable first-line treatment of inoperable, larger HCC, and inverse probability of treatment weighting to adjust for imbalances in treatment assignment is applied.
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Cardiac Events After Radiation Therapy: Combined Analysis of Prospective Multicenter Trials for Locally Advanced Non-Small-Cell Lung Cancer.
TLDR
The 24-month cumulative incidence of grade ≥ 3 cardiac events exceeded 10% among patients with locally advanced NSCLC treated with definitive radiation, and pre-existing cardiac disease and higher mean heart dose were significantly associated with higher cardiac event rates.
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Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11.
TLDR
It is demonstrated that radiotherapy induces tumor cell ferroptosis, an unappreciated mechanism and focus for the development of effective combinatorial cancer therapy.
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Functional diffusion map as an early imaging biomarker for high-grade glioma: correlation with conventional radiologic response and overall survival.
TLDR
Compared with conventional neuroimaging, fDM provided an earlier assessment of equal predictive value, and the combination of fDM and RR provided a more accurate prediction of patient survival than either metric alone.
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Final toxicity results of a radiation-dose escalation study in patients with non-small-cell lung cancer (NSCLC): predictors for radiation pneumonitis and fibrosis.
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