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Protein Footprinting

Known as: Footprinting, Protein 
A method for determining points of contact between interacting proteins or binding sites of proteins to nucleic acids. Protein footprinting utilizes… 
National Institutes of Health

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Papers overview

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2011
2011
Myosin binding surface on actin probed by hydroxyl radical footprinting and site-directed labels.
2008
2008
Mapping cyclic nucleotide‐induced conformational changes in cyclicAMP receptor protein by a protein footprinting technique using different chemical proteases
CyclicAMP receptor protein (CRP) regulates transcription of numerous genes in Escherichia coli. Both cAMP and cGMP bind CRP, but… 
Highly Cited
2005
Highly Cited
2005
Modulation of Replication Protein A Function by Its Hyperphosphorylation-induced Conformational Change Involving DNA Binding Domain B*
Human replication protein A (RPA), composed of RPA70, RPA32, and RPA14 subunits, undergoes hyperphosphorylation in cells in… 
Highly Cited
2003
Highly Cited
2003
Structural Analysis of Gelsolin Using Synchrotron Protein Footprinting*
Protein footprinting provides detailed structural information on protein structure in solution by directly identifying accessible… 
2001
2001
Mapping DNA-binding sites of HIV-1 integrase by protein footprinting.
The HIV-1 integrase protein catalyzes integration of the viral genome into host cell DNA. Whereas the structures of the three… 
1999
1999
Ligand-induced Structural Alterations in Human Iron Regulatory Protein-1 Revealed by Protein Footprinting*
Human iron regulatory protein-1 (IRP-1) is a bifunctional protein that regulates iron metabolism by binding to mRNAs encoding… 
Highly Cited
1998
Highly Cited
1998
The bacteriophage T4 AsiA protein: a molecular switch for sigma 70‐dependent promoters
The AsiA protein, encoded by bacteriophage T4, inhibits Eσ70‐dependent transcription at bacterial and early‐phage promoters. We… 
1998
1998
Mapping substrate-induced conformational changes in cAMP-dependent protein kinase by protein footprinting.
Upon binding of substrates the catalytic subunit (C) of cAMP-dependent protein kinase (cAPK) undergoes significant induced… 
1996
1996
Binding of the sigma 70 protein to the core subunits of Escherichia coli RNA polymerase, studied by iron-EDTA protein footprinting.
We have used a nonspecific protein cleaving reagent to map the interactions between subunits of the multisubunit enzyme RNA… 
1996
1996
Protein footprinting approach to mapping DNA binding sites of two archaeal homing enzymes: evidence for a two-domain protein structure.
The archaeal intron-encoded homing enzymes I-PorI and I-DmoI belong to a family of endonucleases that contain two copies of a… 
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