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Proteasome Pathway

Known as: Proteasome 
The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell… 
National Institutes of Health

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26S Protease Regulatory Subunit 7, humanIFNG wt AlleleInterferon Type IIPSMA5 protein, human

Papers overview

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Review
2008
Review
2008
Proteasome Inhibitors in Cancer Therapy: Lessons from the First Decade
The ubiquitin-proteasome pathway is involved in intracellular protein turnover, and its function is crucial to cellular… 
Highly Cited
2004
Highly Cited
2004
Vif Overcomes the Innate Antiviral Activity of APOBEC3G by Promoting Its Degradation in the Ubiquitin-Proteasome Pathway*
Viruses must overcome diverse intracellular defense mechanisms to establish infection. The Vif (virion infectivity factor… 
Highly Cited
2003
Highly Cited
2003
Degradation of Transcription Factor Nrf2 via the Ubiquitin-Proteasome Pathway and Stabilization by Cadmium*
Nrf2 mediates inducer-dependent activation of the heme oxygenase-1 (HO-1) gene (Alam, J., Stewart, D., Touchard, C., Boinapally… 
Highly Cited
2001
Highly Cited
2001
Proteasome-mediated Glucocorticoid Receptor Degradation Restricts Transcriptional Signaling by Glucocorticoids*
Ligand-dependent down-regulation of the glucocorticoid receptor (GR) has been shown to limit hormone responsiveness, but the… 
Review
1999
Review
1999
The Proteasome, a Novel Protease Regulated by Multiple Mechanisms*
Investigators have long recognized the potential importance of protein degradation as a mechanism for regulating levels of… 
Highly Cited
1998
Highly Cited
1998
Rad23 links DNA repair to the ubiquitin/proteasome pathway
Rad23 is an evolutionarily conserved protein that is important for nucleotide excision repair. A regulatory role has been… 
Highly Cited
1996
Highly Cited
1996
Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation.
Cyclin E is a mammalian G1 cyclin that is both required and rate limiting for entry into S phase. The expression of cyclin E is… 
Highly Cited
1995
Highly Cited
1995
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27.
The p27 mammalian cell cycle protein is an inhibitor of cyclin-dependent kinases. Both in vivo and in vitro, p27 was found to be… 
Highly Cited
1995
Highly Cited
1995
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.
The transcription factor NF-kappa B is sequestered in the cytoplasm by the inhibitor protein I kappa B alpha. Extracellular… 
Highly Cited
1995
Highly Cited
1995
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
The nuclear translocation of NF-kappa B follows the degradation of its inhibitor, I kappa B alpha, an event coupled with… 
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