Proteasome Pathway

Known as: Proteasome 
The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
The ubiquitin proteasome pathway is responsible for most of the protein degradation in mammalian cells. Rates of degradation by… (More)
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Review
2006
Review
2006
A ll intracellular proteins and many extracellular proteins are continually “turning over;” i.e., they are being hydrolyzed to… (More)
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Review
1999
Review
1999
In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteasome pathway. The 26S… (More)
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Highly Cited
1999
Highly Cited
1999
The ubiquitin-proteasome pathway plays a critical role in the regulated degradation of proteins involved in cell cycle control… (More)
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Highly Cited
1998
Highly Cited
1998
Hypoxia induces a group of physiologically important genes such as erythropoietin and vascular endothelial growth factor. These… (More)
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Review
1998
Review
1998
The discovery of the ubiquitin pathway and its many substrates and functions has revolutionized our concept of intracellular… (More)
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Highly Cited
1997
Highly Cited
1997
beta-catenin is a central component of the cadherin cell adhesion complex and plays an essential role in the Wingless/Wnt… (More)
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Highly Cited
1996
Highly Cited
1996
Rb protein is a critical regulator of entry into the cell cycle, and loss of Rb function by deletions, mutations, or interaction… (More)
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Highly Cited
1995
Highly Cited
1995
The p27 mammalian cell cycle protein is an inhibitor of cyclin-dependent kinases. Both in vivo and in vitro, p27 was found to be… (More)
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Highly Cited
1995
Highly Cited
1995
The transcription factor NF-kappa B is sequestered in the cytoplasm by the inhibitor protein I kappa B alpha. Extracellular… (More)
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