• Publications
  • Influence
Antiinflammatory action of glucocorticoids--new mechanisms for old drugs.
Glucocorticoids are among the most common therapeutic agents used in medical practice, yet their mechanisms of action are only partly understood. This review summarizes our understanding of howExpand
  • 2,270
  • 95
  • PDF
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functionalExpand
  • 1,283
  • 73
  • PDF
The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease.
Glucocorticoids are primary stress hormones necessary for life that regulate numerous physiologic processes in an effort to maintain homeostasis. Synthetic derivatives of these hormones have beenExpand
  • 514
  • 35
Molecular control of immune/inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor-signaling pathways.
I. Introduction II. Nuclear Factor-κB (NF-κB) A. Introduction B. NF-κB is a dimeric transcription factor C. The regulatory subunit IκB is an inhibitor of NF-κB D. Activation and function of NF-κB E.Expand
  • 788
  • 30
  • PDF
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise isExpand
  • 646
  • 29
  • PDF
Cellular Processing of the Glucocorticoid Receptor Gene and Protein: New Mechanisms for Generating Tissue-specific Actions of Glucocorticoids*
Glucocorticoids regulate numerous physiological processes and are mainstays in the treatment of inflammation, autoimmune disease, and cancer. The traditional view that glucocorticoids act through aExpand
  • 297
  • 29
  • PDF
The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function.
Alternative splicing of the human glucocorticoid receptor (hGR) primary transcript produces two receptor isoforms, hGRalpha and hGRbeta, which differ at their carboxyl termini. The hGRalpha isoformExpand
  • 553
  • 28
A Primary Role for K+ and Na+ Efflux in the Activation of Apoptosis*
Cell shrinkage is a major characteristic of apoptosis, but the mechanism and role of this process in cell death are poorly understood. The primary factor that controls volume regulation in all cellsExpand
  • 533
  • 25
Glucocorticoid receptor signaling in health and disease.
Glucocorticoids are steroid hormones regulated in a circadian and stress-associated manner to maintain various metabolic and homeostatic functions that are necessary for life. SyntheticExpand
  • 427
  • 25
Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors.
Glucocorticoids are potent immunosuppressants which work in part by inhibiting cytokine gene transcription. We show here that NF-kappa B, an important regulator of numerous cytokine genes, isExpand
  • 839
  • 23