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- Publications
- Influence
Antiinflammatory action of glucocorticoids--new mechanisms for old drugs.
- T. Rhen, J. Cidlowski
- Medicine
- The New England journal of medicine
- 20 October 2005
Glucocorticoids are among the most common therapeutic agents used in medical practice, yet their mechanisms of action are only partly understood. This review summarizes our understanding of how… Expand
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- L. Galluzzi, I. Vitale, +166 authors G. Kroemer
- Biology, Medicine
- Cell Death & Differentiation
- 23 January 2018
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional… Expand
The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease.
- R. H. Oakley, J. Cidlowski
- Biology, Medicine
- The Journal of allergy and clinical immunology
- 1 November 2013
Glucocorticoids are primary stress hormones necessary for life that regulate numerous physiologic processes in an effort to maintain homeostasis. Synthetic derivatives of these hormones have been… Expand
Molecular control of immune/inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor-signaling pathways.
- L. McKay, J. Cidlowski
- Medicine, Biology
- Endocrine reviews
- 1 August 1999
I. Introduction II. Nuclear Factor-κB (NF-κB) A. Introduction B. NF-κB is a dimeric transcription factor C. The regulatory subunit IκB is an inhibitor of NF-κB D. Activation and function of NF-κB E.… Expand
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
- L. Galluzzi, J. M. Bravo-San Pedro, +105 authors G. Kroemer
- Biology, Medicine
- Cell Death and Differentiation
- 19 September 2014
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is… Expand
Cellular Processing of the Glucocorticoid Receptor Gene and Protein: New Mechanisms for Generating Tissue-specific Actions of Glucocorticoids*
- R. H. Oakley, J. Cidlowski
- Biology, Medicine
- The Journal of Biological Chemistry
- 13 December 2010
Glucocorticoids regulate numerous physiological processes and are mainstays in the treatment of inflammation, autoimmune disease, and cancer. The traditional view that glucocorticoids act through a… Expand
The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function.
- R. H. Oakley, M. Sar, J. Cidlowski
- Biology, Medicine
- The Journal of biological chemistry
- 19 April 1996
Alternative splicing of the human glucocorticoid receptor (hGR) primary transcript produces two receptor isoforms, hGRalpha and hGRbeta, which differ at their carboxyl termini. The hGRalpha isoform… Expand
A Primary Role for K+ and Na+ Efflux in the Activation of Apoptosis*
- C. Bortner, F. Hughes, J. Cidlowski
- Biology, Medicine
- The Journal of Biological Chemistry
- 19 December 1997
Cell shrinkage is a major characteristic of apoptosis, but the mechanism and role of this process in cell death are poorly understood. The primary factor that controls volume regulation in all cells… Expand
Glucocorticoid receptor signaling in health and disease.
- M. Kadmiel, J. Cidlowski
- Biology, Medicine
- Trends in pharmacological sciences
- 1 September 2013
Glucocorticoids are steroid hormones regulated in a circadian and stress-associated manner to maintain various metabolic and homeostatic functions that are necessary for life. Synthetic… Expand
Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors.
- R. Scheinman, A. Gualberto, C. Jewell, J. Cidlowski, A. Baldwin
- Biology, Medicine
- Molecular and cellular biology
- 1 February 1995
Glucocorticoids are potent immunosuppressants which work in part by inhibiting cytokine gene transcription. We show here that NF-kappa B, an important regulator of numerous cytokine genes, is… Expand