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Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain homeostatic functions and mediate pathogenic… Expand Prostaglandins are potent lipid molecules that affect key aspects of immunity. The original view of prostaglandins was that they… Expand Prostaglandins and leukotrienes are potent eicosanoid lipid mediators derived from phospholipase-released arachidonic acid that… Expand NF-κB is a critical activator of genes involved in inflammation and immunity. Pro-inflammatory cytokines activate the IκB kinase… Expand I. Introduction II. Molecular Aspects A. PPAR isotypes: identity, genomic organization and chromosomal localization B. DNA… Expand Astrocytes in the brain form an intimately associated network with neurons. They respond to neuronal activity and synaptically… Expand Prostaglandin endoperoxide H synthases (PGHSs) catalyze the conversion of arachidonic acid and O2 to PGH2, the committed step in… Expand 1. Oxygen is a toxic gas - an introductionto oxygen toxicity and reactive species 2. The chemistry of free radicals and related… Expand Microsomes prepared from rabbit or pig aortas transformed endoperoxides (PGG2 or PGH2) to an unstable substance (PGX) that… Expand Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due… Expand