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Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart.
- R. Arceci, A. A. King, M. Simon, S. Orkin, D. Wilson
- Biology, Medicine
- Molecular and cellular biology
- 1 April 1993
It is concluded that GATA-4 is a tissue-specific, retinoic acid-inducible, and developmentally regulated transcription factor that plays a role in gene expression in the heart, intestinal epithelium, primitive endoderm, and gonads. Expand
Why are ruminal cellulolytic bacteria unable to digest cellulose at low pH?
Ruminant animals depend on cellulolytic ruminal bacteria to digest cellulose, but these bacteria cannot resist the low ruminal pH that modern feeding practices can create. Because the cellulolytic… Expand
Characterization and sequence of a Thermomonospora fusca xylanase
TfxA is a thermostable xylanase produced by the thermophilic soil bacterium Thermomonospora fusca that has a broad pH optimum around pH 7 and retains 80% of its maximum activity between pH 5 and 9. Expand
Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro.
It is concluded that, under in vitro conditions, disruption of the Gata-4 gene results in a specific block in visceral endoderm formation in homozygous deficient ES cells, which should yield insights into the regulation of yolk sacEndoderm development and the factors expressed by visceral endODerm that influence differentiation of adjoining ectoderm/mesoderm. Expand
Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary.
GATA-4 and GATA-6 play distinct roles in follicular development and luteinization, and the established role of other Gata-binding proteins in hematopoetic cell differentiation and apoptosis is proposed. Expand
Cloning, expression and characterization of a family 48 exocellulase, Cel48A, from Thermobifida fusca.
The gene for a 104-kDa exocellulase, Cel48A, formerly E6, was cloned from Thermobifida fusca into Escherichia coli and Streptomyces lividans. The DNA sequence revealed a type II cellulose-binding… Expand
Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac development.
The temporal and spacial patterns of Gata-4 expression support a role for this factor in the regulation of cardiac differentiation, analogous to the established role of transcription factor GATA-1 in theregulation of hematopoiesis. Expand
Distinct roles for visceral endoderm during embryonic mouse development.
Recent investigations demonstrating this dual role for visceral endoderm as a provider of both nutrients and developmental cues for the early embryo are highlighted. Expand
Identification of two functionally different classes of exocellulases.
A new nonradioactive technique for determining substrate specificity is described, in which ion-spray mass spectrometry was used to analyze the products of enzymatic digests of cellopentaose labeled with 18O at the reducing end and the distribution of label in the reaction products supports the existence of two functional classes of exocellulases. Expand
Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells.
- D. Dorfman, D. Wilson, G. Bruns, S. Orkin
- Medicine, Biology
- The Journal of biological chemistry
- 15 January 1992
GATA-2 is proposed to be the GATA-binding protein required for PPET-1 gene expression in endothelial cells, and this protein is expressed by a variety of cells, including erythroid, HeLa, and endothelial Cells. Expand