• Publications
  • Influence
Hydroperoxide metabolism in mammalian organs.
Oxidative stress: oxidants and antioxidants
  • H. Sies
  • Chemistry, Medicine
  • Experimental physiology
  • 1 March 1997
TLDR
These low molecular mass antioxidant molecules add significantly to the defense provided by the enzymes superoxide dismutase, catalase and glutathione peroxidases, which are termed ‘oxidative stress’. Expand
Glutathione and its role in cellular functions.
  • H. Sies
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 1 November 1999
Glutathione (GSH) is the major cellular thiol participating in cellular redox reactions and thioether formation. This article serves as introduction to the FRBM Forum on glutathione and emphasizesExpand
Strategies of antioxidant defense
Cellular protection against the deleterious effects of reactive oxidants generated in aerobic metabolism, called oxidative stress, is organized at multiple levels. Defense strategies include threeExpand
Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples.
TLDR
The sum of the reduced and oxidized forms of glutathione can be determined by using a kinetic assay in which catalytic amounts of GSH or GSSG and glutATHione reductase bring about the continuous reduction of 5,5′-dithiobis(2-nitrobenzoic acid) (DTNB) by nicotinamide adenine dinucleotide phosphate (NADPH). Expand
Oxidative stress: a concept in redox biology and medicine
  • H. Sies
  • Biology, Medicine
  • Redox biology
  • 2 January 2015
“Oxidative stress” as a concept in redox biology and medicine has been formulated in 1985; at the beginning of 2015, approx. 138,000 PubMed entries show for this term. This concept has its merits andExpand
Antioxidant activity of carotenoids.
  • W. Stahl, H. Sies
  • Chemistry, Medicine
  • Molecular aspects of medicine
  • 1 December 2003
TLDR
There is increasing evidence from human studies that carotenoids protect the skin against photooxidative damage. Expand
Oxidative stress: from basic research to clinical application.
  • H. Sies
  • Medicine
  • The American journal of medicine
  • 30 September 1991
TLDR
Current evidence in clinical research does not show unequivocal distinction between causal or associative relationships of pro-oxidants to the disease process. Expand
(-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans.
TLDR
The data demonstrate that the human ingestion of the flavanol (-)-epicatechin is, at least in part, causally linked to the reported vascular effects observed after the consumption of flavanol-rich cocoa. Expand
Strategies of antioxidant defense.
  • H. Sies
  • Medicine, Biology
  • European journal of biochemistry
  • 1993
Cellular protection against the deleterious effects of reactive oxidants generated in aerobic metabolism, called oxidative stress, is organized at multiple levels. Defense strategies include threeExpand
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