• Publications
  • Influence
Hydroperoxide metabolism in mammalian organs.
  • 4,051
  • 161
Oxidative stress: oxidants and antioxidants
  • H. Sies
  • Chemistry, Medicine
  • Experimental physiology
  • 1 March 1997
An imbalance between oxidants and antioxidants in favour of the oxidants, potentially leading to damage, is termed ‘oxidative stress’. Oxidants are formed as a normal product of aerobic metabolismExpand
  • 3,826
  • 121
Strategies of antioxidant defense
Cellular protection against the deleterious effects of reactive oxidants generated in aerobic metabolism, called oxidative stress, is organized at multiple levels. Defense strategies include threeExpand
  • 1,462
  • 58
Glutathione and its role in cellular functions.
  • H. Sies
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 1 November 1999
Glutathione (GSH) is the major cellular thiol participating in cellular redox reactions and thioether formation. This article serves as introduction to the FRBM Forum on glutathione and emphasizesExpand
  • 1,400
  • 55
Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples.
Publisher Summary This chapter presents the assay of glutathione (GSH), glutathione disulfide (GSSG), and glutathione mixed disulfides (GSSR). The sum of the reduced and oxidized forms of glutathioneExpand
  • 1,241
  • 50
(-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans.
Epidemiological and medical anthropological investigations suggest that flavanol-rich foods exert cardiovascular health benefits. Endothelial dysfunction, a prognostically relevant key event inExpand
  • 873
  • 43
Antioxidant activity of carotenoids.
  • W. Stahl, H. Sies
  • Medicine, Chemistry
  • Molecular aspects of medicine
  • 1 December 2003
Carotenoids are pigments which play a major role in the protection of plants against photooxidative processes. They are efficient antioxidants scavenging singlet molecular oxygen and peroxylExpand
  • 844
  • 37
Oxidative stress: from basic research to clinical application.
  • H. Sies
  • Medicine
  • The American journal of medicine
  • 1 September 1991
The occurrence of reactive oxygen species, known as pro-oxidants, is an attribute of normal aerobic life. The steady-state formation of pro-oxidants is balanced by a similar rate of their consumptionExpand
  • 1,051
  • 35
Oxidative stress: a concept in redox biology and medicine
  • H. Sies
  • Medicine, Biology
  • Redox biology
  • 2 January 2015
“Oxidative stress” as a concept in redox biology and medicine has been formulated in 1985; at the beginning of 2015, approx. 138,000 PubMed entries show for this term. This concept has its merits andExpand
  • 666
  • 32
Lycopene is more bioavailable from tomato paste than from fresh tomatoes.
Lycopene bioavailability from a single dose of fresh tomatoes or tomato paste (23 mg lycopene) ingested together with 15 g corn oil was compared by analyzing carotenoid concentrations in theExpand
  • 635
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