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Propylthiouracil

Known as: 6-Propyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one, 6-Propyl-2-thio-2,4(1H,3H)pyrimidinedione, 6-Propylthiouracil 
A thiourea derivative with antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with… 
National Institutes of Health

Related topics

Related topics

20 relations

Narrower (1)

1-propyl-4-thiouracil

Broader (3)

AntimetabolitesAntithyroid AgentsThiouracil
Decreased Protein Synthesis [PE]Drug AllergyGoiterIn Blood

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1994
Highly Cited
1994
Rapid stimulation in vitro of rat liver cytochrome oxidase activity by 3,5-diiodo-l-thyronine and by 3,3′-diiodo-l-thyronine
Highly Cited
1979
Highly Cited
1979
Studies on metabolic tolerance to alcohol, hepatomegaly and alcoholic liver disease.
Highly Cited
1978
Highly Cited
1978
Thyroxine 5'-deiodinase activity of rat kidney: observations on activation by thiols and inhibition by propylthiouracil.
Enzymatic 5'-deiodination of T4 in various tissues is known to be stimulated by thiols and inhibited by propylthiouracil (PTU… 
Highly Cited
1978
Highly Cited
1978
Hormone action at the membrane level. VIII. Adrenergic receptors in rat heart and adipocytes and their modulation by thyroxine.
Highly Cited
1977
Highly Cited
1977
Effects of thyroid dysfunction on the development of the rat cerebellum, with special reference to cell death within the internal granular layer
Highly Cited
1977
Highly Cited
1977
Serum triiodothyronine levels in the embryonic and post-hatching chicken, with particular reference to feeding-induced changes.
Highly Cited
1973
Highly Cited
1973
Effects of thyrotropin, prostaglandin E1 and iodide on cyclic 3',5'-AMP concentration in dog thyroid slices.
Highly Cited
1971
Highly Cited
1971
Production of advanced coronary atherosclerosis, myocardial infarction and "sudden death" in swine.
Highly Cited
1968
Highly Cited
1968
An analysis of the action of thyroid hormone on development based on in vivo and in vitro studies.
Highly Cited
1968
Highly Cited
1968
Enhanced biliary excretion of thyroxine glucuronide in rats pretreated with benzpyrene.
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