• Publications
  • Influence
The pharmacology and toxicology of "ecstasy" (MDMA) and related drugs.
  • H. Kalant
  • Medicine
  • CMAJ : Canadian Medical Association journal…
  • 2 October 2001
TLDR
The available evidence does not yet permit an accurate assessment of the size of the problem presented by the use of these drugs, but a detailed review of the literature has revealed over 87 "ecstasy"-related fatalities. Expand
Effects of moderate alcohol consumption on the central nervous system.
TLDR
The cognitive effects of acute and chronic moderate intake of ethanol is reviewed, and although a number of studies have noted a measurable diminution in neuropsychologic parameters in habitual consumers of moderate amounts of ethanol, others have not found such changes. Expand
Adverse effects of cannabis on health: an update of the literature since 1996
  • H. Kalant
  • Medicine
  • Progress in Neuro-Psychopharmacology and…
  • 1 August 2004
TLDR
The evidence indicates that regular heavy use of cannabis carries significant risks for the individual user and for the health care system. Expand
Principles of Medical Pharmacology
I: GENERAL PRINCIPLES Introduction to General Pharmacology Drug solubility, absorption, and movement across body membranes Drug distribution Drug biotransformation Pharmacokinetics Clearance, theExpand
What neurobiology cannot tell us about addiction.
  • H. Kalant
  • Psychology, Medicine
  • Addiction
  • 1 May 2010
TLDR
It is necessary to devise appropriate integrative approaches to the study of addiction, rather than pursue an ever-finer reductive approach which leads steadily farther away from the complex interaction of drug, user, environment and specific situations that characterizes the problem in humans. Expand
Absorption, Diffusion, Distribution, and Elimination of Ethanol: Effects on Biological Membranes
The basic facts of alcohol absorption, distribution, metabolism, and excretion were described clearly many years ago by Nicloux (1900) and Grehant (1907), among others. They showed that alcohol couldExpand
Research on tolerance: what can we learn from history?
  • H. Kalant
  • Medicine, Psychology
  • Alcoholism, clinical and experimental research
  • 1 February 1998
TLDR
A review of the history of past research points to a number of important lessons for future work, including the recognition that learning can play a major role in the development of tolerance to alcohol and cross-tolerance to other drugs. Expand
Motivational properties of ethanol in naive rats as studied by place conditioning
TLDR
Ethanol, in the doses used here, has only punishing or neutral motivational effects in naive rats and does not serve as a primary positive reinforcer in this model, consistent with a proposal that prolonged training and experience with ethanol are important for ethanol self-administration by the rat. Expand
Medicinal use of cannabis: history and current status.
  • H. Kalant
  • Medicine
  • Pain research & management
  • 2001
TLDR
Pure tetrahydrocannabinol and several analogues have shown significant therapeutic benefits in the relief of nausea and vomiting, and stimulation of appetite in patients with wasting syndrome, and recent evidence clearly demonstrates analgesic and anti-spasticity effects that will probably prove to be clinically useful. Expand
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