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Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase.
TLDR
Results obtained in the present study favor the view that both iodination and coupling are mediated by the porphyrin pi-cation radical form of compound I, as well as finding that coupling was inhibited in the presence of excess iodide.
Plasma thyroxine and triiodothyronine levels in spontaneously metamorphosing Rana catesbeiana tadpoles and in adult anuran amphibia.
TLDR
The very low levels of circulating T4 and T3 both in premetamorphosis tadpoles and in adults suggest that thyroid hormones in anuran Amphibia may be of importance only during the period of metamorphosis.
The mechanism of action of the thioureylene antithyroid drugs.
  • A. Taurog
  • Biology, Chemistry
    Endocrinology
  • 1 April 1976
TLDR
A scheme is proposed for the mechanism of inhibition by thioureylene drugs of TPO-catalyzed iodination of protein and tyrosine, which is capable of inhibiting their own and each other's metabolism.
Acute and chronic responses to iodine deficiency in rats.
TLDR
The results suggest that thyroid function in severely iodine deficient rats is not adequate to meet the challenge of acute cold stress, and these animals may be daid to display signs of hypothyroidism.
Hypothyroidism in severely iodine-deficient rats.
TLDR
It is demonstrated that a hypothyroid state can be induced in rats exposed to a severely iodine-deficient diet and measurement of liver alpha-GPD may be a more sensitive index of impending hypothy thyroidism than measurement of O2 consumption.
Effect of iodine deficiency and cold exposure on thyroxine 5'-deiodinase activity in various rat tissues.
TLDR
It is likely that increased thyroxine (T4)-to-T3 conversion in the greatly enlarged thyroids of LID rats contributed to the maintenance of serum T3, and the inability to demonstrate an increase in uncoupling protein mRNA levels in BAT in response to cold makes it unlikely that BAT contributes to maintenance of Serum T3 in LID Rats.
Metabolism of 35S- and 14C-labeled 1-methyl-2-mercaptoimidazole in vitro and in vivo.
TLDR
It was demonstrated that these components do not survive homogenization with thyroid tissue, and failure to detect them in vivo does not exclude them as likely intermediates in intrathyroidal MMI metabolism.
Mechanism of action of thioureylene antithyroid drugs: factors affecting intrathyroidal metabolism of propylthiouracil and methimazole in rats.
TLDR
Results are similar to results previously reported for in vitro oxidation of PTU and MMI by the thyroid peroxidase system, and they offer support for the physiological significance of this scheme.
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