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  • Influence
Identification of alcohol abuse using laboratory tests and a history of trauma.
In a study involving 68 ambulatory patients with known alcohol problems and 68 social drinkers matched for age and sex, a questionnaire about the patients' history of trauma identified 7 out of 10Expand
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Assessment of Prognostic Factors in Alcoholic Liver Disease: Toward a Global Quantitative Expression of Severity
The prognostic significance of a battery of clinical, laboratory, and histological indicators was assessed in relation to mortality risk in a 1‐year study of 253 patients with alcoholic liverExpand
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Ethanol as a prodrug: brain metabolism of ethanol mediates its reinforcing effects.
BACKGROUND  While the molecular entity responsible for the rewarding effects of virtually all drugs of abuse is known, that for ethanol remains uncertain. Some lines of evidence suggest that theExpand
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Genetic selection for high and low alcohol consumption in a limited-access paradigm.
BACKGROUND Several rat lines have been bred for their differences in alcohol consumption based on a continuous-access paradigm in which alcohol solution is available 24 hr/day. The limited-accessExpand
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Reward and relapse: complete gene-induced dissociation in an animal model of alcohol dependence.
BACKGROUND In animal models of continuous alcohol self-administration, in which physical dependence does not constitute the major factor of ethanol intake, 2 factors likely contribute to theExpand
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New insights on the mechanism of the alcohol-induced increase in portal blood flow.
Acute administration of ethanol increases portal blood flow by 40-60%. This increase in blood flow compensates for the increase in O2 consumption that follows alcohol intake and may play a protectiveExpand
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Polymorphisms of the D4 dopamine receptor alleles in chronic alcoholism.
We have screened genomic DNA for the identification of D4 dopamine receptor polymorphisms. We show that the D4 dopamine receptor genotype in 72 severely affected chronic alcoholics is heterogeneous,Expand
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REVIEW: The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake
Ethanol non‐drinker (UChA) and drinker (UChB) rat lines derived from an original Wistar colony have been selectively bred at the University of Chile for over 70 generations. Two main differencesExpand
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Monoclonal and polyclonal antibodies against acetaldehyde-containing epitopes in acetaldehyde-protein adducts.
Immunization of mice with acetaldehyde conjugated to human plasma proteins resulted in the production of polyclonal antibodies that reacted with erythrocyte protein-acetaldehyde conjugates, but notExpand
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Cytochrome P4502E1 hydroxyethyl radical adducts as the major antigen in autoantibody formation among alcoholics.
BACKGROUND & AIMS We have previously reported that alcoholics have increased titers of immunoglobulins reacting with protein adducts of hydroxyethyl free radicals. Because hydroxyethyl radicals areExpand
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