Proinsulin

Known as: Proinsulin [Chemical/Ingredient] 
A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1967-2017
020406019672017

Papers overview

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Highly Cited
2011
Highly Cited
2011
OBJECTIVE Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with… (More)
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Highly Cited
2008
Highly Cited
2008
Variation within six novel genetic loci has been reported to confer risk of type 2 diabetes and may be associated with beta cell… (More)
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Highly Cited
2003
Highly Cited
2003
Accumulating evidence favors a role for proinsulin as a key autoantigen in diabetes. In the mouse, two proinsulin isoforms… (More)
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Highly Cited
2003
Highly Cited
2003
Autosomal dominant diabetes in the Akita mouse is caused by mutation of the insulin 2 gene, whose product replaces a cysteine… (More)
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Highly Cited
2000
Highly Cited
2000
  • A Festa, R D'Agostino, G Howard, L Mykkänen, Russell P Tracy, S M Haffner
  • Circulation
  • 2000
BACKGROUND Inflammation has been suggested as a risk factor for the development of atherosclerosis. Recently, some components of… (More)
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Highly Cited
1996
Highly Cited
1996
We studied the intra-individual variation in plasma glucose, specific serum insulin and serum pro-insulin concentrations… (More)
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Highly Cited
1988
Highly Cited
1988
Glucose is a well-known stimulus of proinsulin biosynthesis. In purified beta cells, the sugar induces a 25-fold increase in the… (More)
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Highly Cited
1980
Highly Cited
1980
Glucose is known to stimulate proinsulin synthesis in pancreatic islets of rats as well as of many other animals1, but the… (More)
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Highly Cited
1978
Highly Cited
1978
The complete amino acid sequence of human insulin-like growth factor I (IGF-I), a polypeptide isolated from serum, has been… (More)
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Highly Cited
1975
Highly Cited
1975
Concentrations of insulin, proinsulin, and C-peptide were measured in portal and peripheral venous blood in six nondiabetic… (More)
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