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Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion
It is demonstrated that SGLT2 is expressed in glucagon-secreting alpha cells of the pancreatic islets, and dapagliflozin treatment further promotes glucagon secretion and hepatic gluconeogenesis in healthy mice, thereby limiting the decrease of plasma glucose induced by fasting. Expand
L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase
Data is presented consistent with the idea that BCH induces insulin release through the allosteric activation of glutamate dehydrogenase, which is compatible with the fuel hypothesis, which states that the secretory response to nutrient secretagogues depends always on an increase of catabolic fluxes in the islet cells. Expand
Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid.
The activation of glutamate dehydrogenase by BCH may account for the insulin-releasing capacity of the leucine analog and be responsible for the dose-related increase in 14CO2 output from islets prelabeled with L-[U-14C]glutamine. Expand
Impaired activity of rat pancreatic islet mitochondrial glycerophosphate dehydrogenase in protein malnutrition.
Findings support the view that an impaired activity of pancreatic B-cell mitochondrial glycerophosphate dehydrogenase contributes, possibly in association with other enzymatic anomalies, to the perturbation of islet function in protein malnutrition. Expand
Dietary sardine protein lowers insulin resistance, leptin and TNF-α and beneficially affects adipose tissue oxidative stress in rats with fructose-induced metabolic syndrome.
Results support the beneficial effect of sardine protein in fructose-induced metabolic syndrome on such variables as hyperglycemia, insulin resistance, hyperlipidemia and oxidative and inflammatory status, suggesting the possible use of sardsine protein as a protective strategy against insulin resistance and related situations. Expand
Determinants of the selective toxicity of alloxan to the pancreatic B cell.
The findings suggest that the selective cytotoxicity of alloxan to the pancreatic B cell is attributable to the conjunction of two features: a rapid cellular uptake of the drug and an exquisite sensitivity of the B cell to peroxide. Expand
d-Glucose and l-leucine metabolism in neonatal and adult cultured rat pancreatic islets
Neonatal and adult rat islets, cultured for 7-9 days in the presence of 10.5 mM D-glucose, were incubated for 120 min with either D-glucose (2.8 and 16.7 mM) or L-leucine (1.0 and 20.0 mM). The totalExpand
Insulin release: the fuel hypothesis.
It is proposed that such a coupling between metabolic and cationic events is operative in response to other insulinotropic nutrients and that its time course may be relevant to the phasic aspect of insulin release. Expand
Metabolic effects and fate of succinate esters in pancreatic islets.
It is proposed that a concerted increase of both succinate and acetyl residue influx into the Krebs cycle accounts for the increase in O2 uptake caused by the succinate methyl esters and, hence, for stimulation of both pro-insulin biosynthesis and insulin release. Expand
Insulinotropic action of AICA riboside. II. Secretory, metabolic and cationic aspects.
Preincubation of rat pancreatic islets with AICA riboside (0.1 to 1.0mM) caused a concentration-related stimulation of both 45Ca net uptake and insulin release evoked by 8.3 mM D-glucose, but failedExpand