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INS gene

Known as: INSULIN, Insulin Gene, INS-IGF2 SPLICED READ-THROUGH TRANSCRIPTS 
This gene plays a role in insulin and glucose regulation.
National Institutes of Health

Related topics

Related topics

16 relations
C-PeptideDiabetes MellitusEnergy MetabolismGlycolysis

Broader (1)

Genes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1997
Highly Cited
1997
Release of Incompletely Processed Proinsulin Is the Cause of the Disproportionate Proinsulinemia of NIDDM
The production of insulin from proinsulin involves cleavage of intact proinsulin into proinsulin conversion intermediates by the… 
Highly Cited
1994
Highly Cited
1994
Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression
The insulin gene is expressed exclusively in pancreatic islet beta cells. The principal regulator of insulin gene transcription… 
Highly Cited
1993
Highly Cited
1993
Localization of a Type I Diabetes Susceptibility Locus to the Variable Tandem Repeat Region Flanking the Insulin Gene
A susceptibility gene for type I diabetes is present on chromosome 11p15.5, but its location, identity, and mechanism of action… 
Review
1993
Review
1993
Processing of Protein Precursors by a Novel Family of Subtilisin-Related Mammalian Endoproteases
The recent identification of a novel family of mammalian endoproteases that carry out intracellular processing of protein… 
Highly Cited
1990
Highly Cited
1990
NMR and photo-CIDNP studies of human proinsulin and prohormone processing intermediates with application to endopeptidase recognition.
The proinsulin-insulin system provides a general model for the proteolytic processing of polypeptide hormones. Two proinsulin… 
Highly Cited
1984
Highly Cited
1984
Toxicity of an overproduced foreign gene product in Escherichia coli and its use in plasmid vectors for the selection of transcription terminators.
Highly Cited
1982
Highly Cited
1982
Rapid Publications Restriction Fragment Length Polymorphism of the Insulin Gene in Diabetes Mellitus
DAVID OWERBACH AND J0RN NERUP SUMMARY Variant DNA sequences flanking the human insulin gene were found in the Danish population… 
Highly Cited
1981
Highly Cited
1981
Polymorphism in the 5'-flanking region of the human insulin gene and its possible relation to type 2 diabetes.
The arrangement of the human insulin gene in DNA from 87 individuals was analyzed by the Southern blot hybridization technique… 
Highly Cited
1980
Highly Cited
1980
Analysis of the regions flanking the human insulin gene and sequence of an Alu family member.
The regions around the human insulin gene have been studied by heteroduplex, hybridization and sequence analysis. These studies… 
Highly Cited
1980
Highly Cited
1980
Genetic variation in the human insulin gene.
Four recombinant lambda phages containing nucleotide sequences complementary to a cloned human preproinsulin DNA probe have been… 
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