PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
- V. Mootha, C. Lindgren, L. Groop
- BiologyNature Genetics
- 1 July 2003
An analytical strategy is introduced, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes, which identifies a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle.
Genetic studies of body mass index yield new insights for obesity biology
- A. Locke, Bratati Kahali, E. Speliotes
- BiologyNature
- 11 February 2015
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility.
Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids
- Tanya M. Teslovich, K. Musunuru, S. Kathiresan
- BiologyNature
- 1 August 2010
The results identify several novel loci associated with plasma lipids that are also associated with CAD and provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD.
Cardiovascular morbidity and mortality associated with the metabolic syndrome.
- B. Isomaa, P. Almgren, L. Groop
- MedicineDiabetes Care
- 1 April 2001
The WHO definition of the metabolic syndrome identifies subjects with increased cardiovascular morbidity and mortality and offers a tool for comparison of results from diferent studies.
Age-related clonal hematopoiesis associated with adverse outcomes.
- S. Jaiswal, P. Fontanillas, B. Ebert
- MedicineNew England Journal of Medicine
- 24 December 2014
Age-related clonal hematopoiesis is a common condition that is associated with increases in the risk of hematologic cancer and in all-cause mortality, with the latter possibly due to an increased risk of cardiovascular disease.
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- E. Speliotes, C. Willer, R. Loos
- Biology, Medicine
- 2010
18 new loci associated with body mass index are identified, one of which includes a copy number variant near GPRC5B, and genes in other newly associated loci may provide new insights into human body weight regulation.
Discovery and Refinement of Loci Associated with Lipid Levels
- C. Willer, Ellen M. Schmidt, G. Abecasis
- BiologyNature Genetics
- 6 October 2013
It is found that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index.
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
- C. Willer, E. Speliotes, J. Hirschhorn
- BiologyNature Genetics
- 2009
Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
- J. Dupuis, C. Langenberg, I. Barroso
- Medicine, BiologyNature Genetics
- 17 January 2010
It is demonstrated that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
- R. Saxena, B. Voight, S. Purcell
- Biology, MedicineScience
- 1 June 2007
The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.
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