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Impact of Medical Student Research in the Development of Physician-Scientists
Context A decline in the number of physician-scientists has been identified in the United States for at least two decades. Although many mechanisms have been proposed to reverse this trend, most ofExpand
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A critical role of Sp1 transcription factor in regulating gene expression in response to insulin and other hormones.
Specificity protein 1 (Sp1) belongs to a family of ubiquitously expressed, C(2)H(2)-type zinc finger-containing DNA binding proteins that activate or repress transcription of many genes in responseExpand
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Composite pheochromocytoma-ganglioneuroma: a rare experiment of nature.
OBJECTIVE To present a rare case of composite pheochromocytoma-ganglioneuroma (Pheo-GN) of the adrenal medulla, review the related literature, and discuss the clinical features, pathologic findings,Expand
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Glucose Intolerance Due to Insulin Resistance in Patients with Spinal Cord Injuries
SUMMARY Glucose intolerance occurs frequently in patients with spinal cord injury (SCI). To characterize this better, 45 patients with spinal cord injuries received oral glucose tolerance testsExpand
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O-glycosylation of Sp1 and transcriptional regulation of the calmodulin gene by insulin and glucagon.
Both insulin and glucagon stimulate steady-state levels of Sp1 transcription factor, but only insulin stimulates transcription of the calmodulin (CaM) gene in liver. Because O-glycosylation of Sp1 byExpand
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TNF-alpha inhibits insulin action in liver and adipose tissue: A model of metabolic syndrome.
Several studies suggest that TNF-alpha contributes to the development of insulin resistance (IR). We compared transcriptional profiles of rat H-411E liver cells exposed to insulin in the absence orExpand
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Insulin Dynamically Regulates Calmodulin Gene Expression by Sequential O-Glycosylation and Phosphorylation of Sp1 and Its Subcellular Compartmentalization in Liver Cells*
O-Glycosylation and phosphorylation of Sp1 are thought to modulate the expression of a number of genes in normal and diabetic state. Sp1 is an obligatory transcription factor for constitutive andExpand
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Functional characterization of two‐dimensional gel‐separated proteins using sequential staining
Proteins separated by two‐dimensional (2‐D) gel electrophoresis can be visualized using various protein staining methods. This is followed by downstream procedures, such as image analysis, gel spotExpand
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In vivo growth hormone treatment stimulates secretion of very low density lipoprotein by the isolated perfused rat liver.
We have previously demonstrated in hepatocyte suspensions prepared after in vivo GH deprivation [hypophysectomy (hypox)] that rates of esterification of [1-14C]oleic acid into triglyceride (TG) andExpand
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Insulin stimulates and diabetes inhibits O-linked N-acetylglucosamine transferase and O-glycosylation of Sp1.
Insulin stimulates both the biosynthesis of transcription factor Sp1 and its O-linked N-acetylglucosaminylation (O-GlcNAcylation), which promotes nuclear localization of Sp1 and its ability toExpand
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