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The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency.
It is concluded that growth hormone has a role in the regulation of body composition in adults, probably through its anabolic and lipolytic actions. Expand
The growth hormone deficiency syndrome in adults
The aims of this review are to summarize the recent studies of GH treatment in adults with GH deficiency, thereby defining the syndrome of GH deficiency in adults, and to highlight areas for future investigation. Expand
Use of a biothesiometer to measure individual vibration thresholds and their variation in 519 non-diabetic subjects.
The biothesiometer provides a quick and reliable assessment of vibration thresholds, which when related to the centile charts gives an objective measure of the progress of diabetic peripheral neuropathy. Expand
Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency.
The effects of 6 months' treatment with recombinant human growth hormone (rhGH) on serum lipids and lipoproteins were assessed in 24 adult patients with GH deficiency in a double-blind,Expand
Responses of markers of bone and collagen turnover to exercise, growth hormone (GH) administration, and GH withdrawal in trained adult males.
It is concluded that endurance exercise transiently activates bone and collagen turnover and brief GH administration results in similar but quantitatively greater augmentation; and these data will assist in designing a GH detection strategy. Expand
The role of the growth hormone–insulin‐like growth factor axis in glucose homeostasis
Evidence suggests that GH secretion is abnormally increased as a result of reduced portal insulin resulting in impaired hepatic IGF‐I generation, and this may contribute to the development of diabetic microvascular complications. Expand
The growth hormone/insulin-like growth factor-I axis in exercise and sport.
There is evidence that exercise performance and strength are improved by administration of GH and testosterone in combination to elderly subjects, and the potential benefits of GH in these situations must be weighed against potential adverse effects. Expand
Psychological well-being before and after growth hormone treatment in adults with growth hormone deficiency.
Significant lower scores on quality of life assessment in the GH-deficient patients at entry compared with matched controls are reported, indicating that this population may be psychologically compromised. Expand