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Procaine

Known as: ?-(diethylamino)ethyl p-aminobenzoate, Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, Procainum 
A benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Constrained analogues of procaine were synthesized, and their inhibiting activity against DNMT1 was tested. Among them, the most… Expand
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Highly Cited
2006
Highly Cited
2006
DNA methyltransferase inhibitors represent promising new drugs for cancer therapies. The first of these compounds (5-azacytidine… Expand
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Highly Cited
2003
Highly Cited
2003
Methylation-associated silencing of tumor suppressor genes is recognized as being a molecular hallmark of human cancer. Unlike… Expand
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Review
2002
Review
2002
Kava-kava (Piper methysticum G. Forster) has been used in social and ceremonial life in the Pacific islands from ancient times… Expand
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Highly Cited
2001
Highly Cited
2001
Determinants of Longevity. The Potential of Diet to Alter Disease Processes. The Role of Plant-Derived Drugs and Herbal Medicines… Expand
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Highly Cited
1996
Highly Cited
1996
Voltage-gated Na+ channels are the molecular targets of local anesthetics, class I antiarrhythmic drugs, and some anticonvulsants… Expand
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Highly Cited
1992
Highly Cited
1992
We prospectively studied 952 patients to identify the incidence of hypotension (systolic blood pressure less than 90 mmHg… Expand
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Highly Cited
1991
Highly Cited
1991
Calcium-induced calcium release (CICR) may function widely in calcium-mediated cell signaling, but has been most thoroughly… Expand
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Highly Cited
1976
Highly Cited
1976
125I-labeled human epidermal growth factor (hEGF) binds in a specific and saturable manner to human fibroblasts. At 37 degrees C… Expand
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Highly Cited
1954
Highly Cited
1954
This study determines as accurately as possible the death rate (and why deaths occurred) attributable to anesthesia whether due… Expand
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