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Probable Transcription Factor PML

Known as: Promyelocytic Leukemia Protein, TRIM19, Transcription Factor PML 
Protein PML (882 aa, ~98 kDa) is encoded by the human PML gene. This protein plays a role in both transcriptional regulation and PML body formation.
National Institutes of Health

Related topics

Related topics

14 relations
DNA-Binding ProteinsGenes, RegulatorNegative Regulation of Cell CyclePML gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Molecular and Cellular Pathobiology The SUMOE 3-ligase PIAS 1 Regulates the Tumor Suppressor PML and Its Oncogenic Counterpart PML-RARA
The ubiquitin-like SUMO proteins covalently modify protein substrates and regulate their functional properties. In a broad… 
Highly Cited
2006
Highly Cited
2006
Perfectly matched multiscale simulations for discrete lattice systems: Extension to multiple dimensions
Extending the technique of the perfectly matched layer (PML) to discrete lattice systems, a multiscale method was proposed by To… 
Highly Cited
2005
Highly Cited
2005
Use of a Combined Ex Vivo/In Vivo Population Approach for Screening of Human Genes Involved in the Human Immunodeficiency Virus Type 1 Life Cycle for Variants Influencing Disease Progression
ABSTRACT Humans differ substantially with respect to susceptibility to human immunodeficiency virus type 1 (HIV-1). We evaluated… 
Highly Cited
2003
Highly Cited
2003
PML Residue Lysine 160 Is Required for the Degradation of PML Induced by Herpes Simplex Virus Type 1 Regulatory Protein ICP0
ABSTRACT During the early stages of herpes simplex virus type 1 (HSV-1) infection, viral immediate-early regulatory protein ICP0… 
Review
2003
Review
2003
Retinoid target genes in acute promyelocytic leukemia
All-trans-retinoic acid (RA)-based differentiation therapy induces clinical remissions in acute promyelocytic leukemia (APL… 
Highly Cited
2002
Highly Cited
2002
Response to histone deacetylase inhibition of novel PML/RARalpha mutants detected in retinoic acid-resistant APL cells.
Resistance to all-trans retinoic acid (ATRA) remains a clinical problem in the treatment of acute promyelocytic leukemia (APL… 
Highly Cited
1997
Highly Cited
1997
Stable overexpression of PML alters regulation of cell cycle progression in HeLa cells.
Our previous studies demonstrated that PML is a growth suppressor that suppresses oncogenic transformation of NIH/3T3 cells and… 
Highly Cited
1995
Highly Cited
1995
Effect of PML and PML-RAR on the transactivation properties and subcellular distribution of steroid hormone receptors.
PML (promyelocytic leukemia) is a protein involved in the t (15;17) translocation of promyelocytic leukemia and is mainly… 
Highly Cited
1992
Highly Cited
1992
A PML/retinoic acid receptor alpha fusion transcript is constantly detected by RNA-based polymerase chain reaction in acute promyelocytic leukemia.
The t(15;17) translocation is specifically observed in patients with promyelocytic leukemia (AML3). The chromosomal rearrangement… 
Highly Cited
1991
Highly Cited
1991
A unique bipartite cysteine-histidine motif defines a subfamily of potential zinc-finger proteins.
Recently, a new potential zinc finger motif was described of the class C , C 2 X C 3 H C 4 C 5 X C 6 C 7 (C3HC4) where the two… 
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