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Probable Transcription Factor PML

Known as: Promyelocytic Leukemia Protein, TRIM19, Transcription Factor PML 
Protein PML (882 aa, ~98 kDa) is encoded by the human PML gene. This protein plays a role in both transcriptional regulation and PML body formation.
National Institutes of Health

Related topics

Related topics

14 relations
DNA-Binding ProteinsGenes, RegulatorNegative Regulation of Cell CyclePML gene

Papers overview

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Highly Cited
2006
Highly Cited
2006
Identification of a tumour suppressor network opposing nuclear Akt function
The proto-oncogene AKT (also known as PKB) is activated in many human cancers, mostly owing to loss of the PTEN tumour suppressor… 
Review
2002
Review
2002
Alternative lengthening of telomeres in mammalian cells
Some immortalized mammalian cell lines and tumors maintain or increase the overall length of their telomeres in the absence of… 
Review
2000
Review
2000
The transcriptional role of PML and the nuclear body
The PML gene encodes a tumour suppressor protein associated with a distinct subnuclear domain, the nuclear body. Various… 
Highly Cited
2000
Highly Cited
2000
The function of PML in p53-dependent apoptosis
The PML gene of acute promyelocytic leukaemia (APL) encodes a growth- and tumour-suppresor protein that is essential for several… 
Highly Cited
2000
Highly Cited
2000
Regulation of p53 activity in nuclear bodies by a specific PML isoform
Covalent modification of the promyelocytic leukaemia protein (PML) by SUMO‐1 is a prerequisite for the assembly of nuclear bodies… 
Highly Cited
2000
Highly Cited
2000
Sequestration and Inhibition of Daxx-Mediated Transcriptional Repression by PML
ABSTRACT PML fuses with retinoic acid receptor α (RARα) in the t(15;17) translocation that causes acute promyelocytic leukemia… 
Highly Cited
1998
Highly Cited
1998
Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL
Acute promyelocytic leukaemia (APL), associated with chromosomal translocations involving the retinoic acid receptor α gene (RARA… 
Highly Cited
1998
Highly Cited
1998
Role of PML in cell growth and the retinoic acid pathway.
The PML gene is fused to the retinoic acid receptor alpha (RARalpha) gene in chromosomal translocations associated with acute… 
Highly Cited
1998
Highly Cited
1998
Identification of Three Major Sentrinization Sites in PML*
Acute promyelocytic leukemia arises following a reciprocal chromosome translocation t(15;17), which generates PML-retinoic acid… 
Highly Cited
1991
Highly Cited
1991
Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia.
The translocation t(15;17) associated with acute promyelocytic leukemia results in the fusion of the retinoic acid receptor alpha… 
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