Probable Transcription Factor PML

Known as: Promyelocytic Leukemia Protein, TRIM19, Transcription Factor PML 
Protein PML (882 aa, ~98 kDa) is encoded by the human PML gene. This protein plays a role in both transcriptional regulation and PML body formation.

Topic mentions per year

Topic mentions per year

1976-2017
0204019762017

Papers overview

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Highly Cited
2010
Highly Cited
2010
Many different molecular mechanisms have been associated with PML-RARalpha-dependent transformation of hematopoietic progenitors… (More)
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Highly Cited
2008
Highly Cited
2008
Retinoic acid and arsenic trioxide target the protein stability and transcriptional repression activity of the fusion oncoprotein… (More)
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Highly Cited
2006
Highly Cited
2006
Promyelocytic leukemia (PML) nuclear bodies (also known as ND10) are nuclear substructures that contain several proteins… (More)
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Highly Cited
2006
Highly Cited
2006
Several viruses, including human cytomegalovirus (HCMV), encode proteins that colocalize with a cellular subnuclear structure… (More)
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Highly Cited
2004
Highly Cited
2004
The p53 tumor suppressor promotes cell cycle arrest or apoptosis in response to stress. Previous work suggests that the… (More)
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Highly Cited
2002
Highly Cited
2002
The yeast Sir2 protein mediates chromatin silencing through an intrinsic NAD-dependent histone deacetylase activity. Sir2 is a… (More)
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Highly Cited
2001
Highly Cited
2001
Promyelocytic leukemia (PML) is the organizer of nuclear matrix domains, PML nuclear bodies (NBs), with a proposed role in… (More)
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Highly Cited
1999
Highly Cited
1999
The PML protein is associated to nuclear bodies (NBs) whose functions are as yet unknown. PML and two other NBs-associated… (More)
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Highly Cited
1998
Highly Cited
1998
The PML protein, identified first as part of the oncogenic PML-RARalpha chimera in acute promyelocytic leukemia (APL… (More)
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Highly Cited
1996
Highly Cited
1996
It has been shown recently in China that arsenic trioxide (As2O3) is a very effective treatment for acute promyelocytic leukemia… (More)
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