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A novel retinoic acid receptor beta isoform and retinoid resistance in lung carcinogenesis.
TLDR
Restoration of RARbeta1' expression may overcome retinoid resistance in lung carcinogenesis and restore target gene expression in RA-resistant BEAS-2B-R1 cells. Expand
Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Represses Cyclin D1 in Aerodigestive Tract Cancers
TLDR
These in vitro and in vivo findings provide direct evidence for repression of cyclin D1 protein as a surrogate marker of response in aerodigestive tract cancers to erlotinib treatment and provide a rationale for combining an EGFR TKI with an agent that would cooperatively repress cycl in D1 expression in clinical trials for aerodigraphy tract cancer therapy or chemoprevention. Expand
Specific Chemopreventive Agents Trigger Proteasomal Degradation of G1 Cyclins: Implications for Combination Therapy
TLDR
Specific chemopreventive agents activate cyclin proteolysis, and broad resistance did not occur after acquired resistance to a single agent, providing a therapeutic rationale for combination Chemoprevention with agents activating non-cross-resistant pathways. Expand
A Proof-of-Principle Clinical Trial of Bexarotene in Patients with Non–Small Cell Lung Cancer
TLDR
Bexarotene represses proliferation and biomarker expression in responsive, but not resistant HBE and lung cancer cells, and similar biomarker changes occur in lung tumors when therapeutic intratumoral bexarotenes levels are achieved. Expand
Retinoid target genes in acute promyelocytic leukemia
TLDR
This review builds on prior work by addressing the role of Retinoid target genes in mediating retinoid response or resistance in APL by identifying potential therapeutic targets. Expand
Bexarotene and erlotinib for aerodigestive tract cancer.
TLDR
Combining erlotinib with bexarotene enhanced growth suppression in vitro compared with each single-agent treatment, and these findings are encouraging and warrant further investigation of this regimen. Expand
Microarray Analyses Uncover UBE1L as a Candidate Target Gene for Lung Cancer Chemoprevention
TLDR
Findings directly implicate UBE1L as a candidate-pharmacologic target for lung cancer chemoprevention and provide a mechanistic basis for the tumor suppressive effects of UBE 1L through cyclin D1 repression. Expand
Distinct functions of retinoic acid receptor beta isoforms: implications for targeted therapy.
TLDR
Discerning isoform-specific functions will be critical for exploiting the full potential of retinoid-based therapy including rational approaches to combining retinoids with chromatin modifying drugs. Expand
Cyclin D1 as a target for chemoprevention.
TLDR
Pre-clinical and clinical studies indicate that cyclin D1 and perhaps other cyclins are attractive pharmacological targets for lung cancer chemoprevention. Expand
An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases
TLDR
An inhalable nano-STING agonist is engineer, which synergizes with fractionated radiation to control lung metastases and confers long-term systemic antitumor immunity in mice, eliciting systemic anticancer immunity. Expand
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