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Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
It is suggested that Foxo1 regulates the homeostasis and life span of naive T cells by sensing growth factor availability and regulating homing and survival signals.
Conjugation with the ubiquitin‐related modifier SUMO‐1 regulates the partitioning of PML within the nucleus
It is shown that, in APL cells, As2O3 triggers rapid degradation of PML–RARα and provokes the restoration of intact nuclear bodies, suggesting that post‐translational modification by SUMO‐1 may be more generally involved than previously suspected in the targeting of proteins to distinct subcellular structures.
The Nucleoporin RanBP2 Has SUMO1 E3 Ligase Activity
Role of SUMO-1-modified PML in nuclear body formation.
It is shown that in the absence of PML, several NB proteins such as Sp100, CBP, ISG20, Daxx, and SUMO-1 fail to accumulate in the NB and acquire aberrant localization patterns, shedding new light on both the mechanisms underlying the formation of the NBs and the pathogenesis of APL.
The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR
Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1α
- C. Muchardt, Marie Guilleme, J. Seeler, D. Trouche, A. Dejean, M. Yaniv
- Biology, ChemistryEMBO reports
- 1 October 2002
It is shown that the association of HP1α with pericentromeric heterochromatin depends not only on its methyl‐binding chromo domain but also on an RNA‐binding activity present in the hinge region of the protein that connects the conserved chromo and chromoshadow domains.
Viral Immediate-Early Proteins Abrogate the Modification by SUMO-1 of PML and Sp100 Proteins, Correlating with Nuclear Body Disruption
This observation supports a model in which ICP0 and IE1 disrupt the NBs either by preventing the formation or by degrading of the SUMO-1-modified PML and Sp100 protein species.
Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells
Nuclear and unclear functions of SUMO
This work has shown that post-translational modification by the ubiquitin-like SUMO protein is emerging as a defining feature of eukaryotic cells.
p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
By transactivating expression of miRNAs that repress expression of the ZEB1 and ZEB2 transcription factors, p53 inhibits the epithelial–mesenchymal transition.