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The Nucleoporin RanBP2 Has SUMO1 E3 Ligase Activity
Posttranslational modification with SUMO1 regulates protein/protein interactions, localization, and stability. SUMOylation requires the E1 enzyme Aos1/Uba2 and the E2 enzyme Ubc9. A family of E3-likeExpand
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Conjugation with the ubiquitin‐related modifier SUMO‐1 regulates the partitioning of PML within the nucleus
The PML protein, identified first as part of the oncogenic PML–RARα chimera in acute promyelocytic leukemia (APL), concentrates within discrete subnuclear structures, corresponding to some types ofExpand
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Role of SUMO-1-modified PML in nuclear body formation.
The tumor-suppressive promyelocytic leukemia (PML) protein of acute promyelocytic leukemia (APL) has served as one of the defining components of a class of distinctive nuclear bodies (NBs). PML isExpand
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p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
By transactivating expression of miRNAs that repress expression of the ZEB1 and ZEB2 transcription factors, p53 inhibits the epithelial–mesenchymal transition.
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Nuclear and unclear functions of SUMO
  • J. Seeler, A. Dejean
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 1 September 2003
Post-translational modification by the ubiquitin-like SUMO protein is emerging as a defining feature of eukaryotic cells. Sumoylation has crucial roles in the regulatory challenges that face nucleateExpand
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Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells
Acute promyelocytic leukemia (APL) is characterized by a specific t(15;17) translocation that fuses the retinoic acid receptor alpha (RAR alpha) to a novel gene product, PML. The involvement of RARExpand
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Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1α
In mammalian cells, as in Schizosaccharomyces pombe and Drosophila, HP1 proteins bind histone H3 tails methylated on lysine 9 (K9). However, whereas K9‐methylated H3 histones are distributedExpand
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The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase
Transcriptional repression mediated through histone deacetylation is a critical component of eukaryotic gene regulation. Here we demonstrate that the class II histone deacetylase HDAC4 is covalentlyExpand
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Viral Immediate-Early Proteins Abrogate the Modification by SUMO-1 of PML and Sp100 Proteins, Correlating with Nuclear Body Disruption
ABSTRACT PML nuclear bodies (NBs) are subnuclear structures whose integrity is compromised in certain human diseases, including leukemia and neurodegenerative disorders. Infection by a number of DNAExpand
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The hepatitis B virus
DNA recombinant technology has radically changed hepatitis B virus (HBV) virology. The genetic organization, transcription and replication of the virus are basically understood, structures ofExpand
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