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Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation
TLDR
The identification of a subset of brain-expressedMiRNAs whose expression behavior is conserved in both mouse and human differentiating neurons implicates these miRNAs in mammalian neuronal development or function. Expand
Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15
TLDR
Results indicated a critical role for ISG15 in the IFN-mediated inhibition of late stages of HIV-1 assembly and release and pointed to a mechanism by which the innate antiviral response targets the cellular endosomal trafficking pathway used by HIV- 1 to exit the cell. Expand
ISG15 enhances the innate antiviral response by inhibition of IRF-3 degradation.
TLDR
The results reveal that virus mediated subversion of the antiviral response by proteolysis of IRF-3 is counteracted by induction of ISG15 expression and that ISGylation provides a feedback mechanism, which enhances the host innate antiviralresponse via IRf-3 stabilization. Expand
Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN.
TLDR
These studies highlight the potential of TPs in retinal cytoprotection and implicate PTEN inhibition as a target in cy toprotection. Expand
Viral defense, carcinogenesis and ISG15: novel roles for an old ISG.
TLDR
The possible role of ISG15 in the antiviral response, regulation of cell growth and carcinogenesis, and its interaction with the ubiquitin conjugation pathway are reviewed. Expand
Abnormal regulation of interferon-gamma, interleukin-12, and tumor necrosis factor-alpha in human interferon-gamma receptor 1 deficiency.
TLDR
Patients with mutations in the IFN-gamma receptor ligand-binding chain who have disseminated nontuberculous mycobacterial infections demonstrate the critical role that theIFN-Gamma receptor plays in the regulation of IFN -gamma, IL-12, and TNF-alpha. Expand
Specific Chemopreventive Agents Trigger Proteasomal Degradation of G1 Cyclins: Implications for Combination Therapy
TLDR
Specific chemopreventive agents activate cyclin proteolysis, and broad resistance did not occur after acquired resistance to a single agent, providing a therapeutic rationale for combination Chemoprevention with agents activating non-cross-resistant pathways. Expand
Involvement of UBE1L in ISG15 Conjugation during Retinoid-induced Differentiation of Acute Promyelocytic Leukemia*
TLDR
It is reported that conjugation of the ubiquitin-like species, interferon-stimulated gene, 15-kDa protein (ISG15), also occurs during RA-induced APL differentiation, and formation of ISG15 conjugates through induction of an activating enzyme represents a novel pharmacologic mechanism for regulation of this ubiquitIn-related species. Expand
UBE1L is a retinoid target that triggers PML/RARα degradation and apoptosis in acute promyelocytic leukemia
TLDR
UBE1L is proposed as a direct pharmacological target that overcomes oncogenic effects of PML/RARα by triggering its degradation and signaling apoptosis in APL cells. Expand
Injury-Mediated Vascular Regeneration Requires Endothelial ER71/ETV2
TLDR
A novel obligatory role for the ETV2 in postnatal vascular repair and regeneration is demonstrated in endothelial Etv2 conditional knockout mice and ischemic injury models, demonstrating an epistatic interaction between ETV1 and FLK1 in vascular regeneration. Expand
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