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Proadifen

Known as: Diethylaminoethyldiphenylpropyl Acetate, Propyladiphenin, Benzeneacetic acid, alpha-phenyl-alpha-propyl-, 2-(diethylamino)ethyl ester 
An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.
National Institutes of Health

Related topics

Related topics

9 relations

Broader (1)

Enzyme Inhibitors
Proadifen Hydrochlorideanalogs & derivativesaspects of radiation effectschemical synthesis
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Narrower (3)

SK&F 8742ASK&F-525-Ameproadifen

Papers overview

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Highly Cited
2013
Highly Cited
2013
Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes.
Smoking is a major risk factor for osteoporosis and fracture, but the mechanism through which smoke causes bone loss remains… Expand
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2008
2008
Identification of binding sites in the nicotinic acetylcholine receptor for TDBzl-etomidate, a photoreactive positive allosteric effector.
Etomidate, one of the most potent general anesthetics used clinically, acts at micromolar concentrations as an anesthetic and… Expand
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Highly Cited
2004
Highly Cited
2004
Hepatobiliary excretion of berberine.
Berberine is a bioactive herbal ingredient isolated from the roots and bark of Berberis aristata or Coptis chinensis. To… Expand
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Highly Cited
2003
Highly Cited
2003
Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes.
The toxicology of the cyanobacterial alkaloid cylindrospermopsin (CYN), a potent inhibitor of protein synthesis, appears complex… Expand
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Highly Cited
2002
Highly Cited
2002
Alkaloid tolerance in Manduca sexta and phylogenetically related sphingids (Lepidoptera: Sphingidae)
SummaryNicotine tolerance is well known for Manduca sexta. It also occurs in several other sphingids of the subfamilies… Expand
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Highly Cited
1999
Highly Cited
1999
Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity.
Diclofenac, a 2-arylacetic acid, nonsteroidal anti-inflammatory drug, has been reported to cause adverse hepatic effects in… Expand
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Highly Cited
1998
Highly Cited
1998
Mechanisms of hydrogen peroxide-induced contraction of rat aorta.
It has been suggested that reactive oxygen species may be involved in the regulation of vascular tone. However, the underlying… Expand
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Highly Cited
1998
Highly Cited
1998
Enhanced acetylcholine induced relaxation in small mesenteric arteries from pregnant rats: an important role for endothelium-derived hyperpolarizing factor (EDHF).
1. Small mesenteric arteries from pregnant rats demonstrated greater sensitivity (pEC50 : P<0.001) and maximum relaxation (P<0.01… Expand
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Highly Cited
1997
Highly Cited
1997
Enzymatic Mechanisms Involved in Phenanthrene Degradation by the White Rot Fungus Pleurotus ostreatus.
The enzymatic mechanisms involved in the degradation of phenanthrene by the white rot fungus Pleurotus ostreatus were examined… Expand
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Highly Cited
1995
Highly Cited
1995
The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype.
1. The effect of administration of 3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy') and its N-demethylated product, 3,4… Expand
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